Barry M Forman
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Explore the profile of Barry M Forman including associated specialties, affiliations and a list of published articles.
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35
Citations
1657
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Recent Articles
1.
Yu D, Van Citters G, Li H, Stoltz B, Forman B
Bioorg Med Chem
. 2021 May;
41:116193.
PMID: 34022528
Nonalcoholic fatty liver disease (NAFLD) is a severe liver disease causing serious liver complications, including nonalcoholic steatohepatitis (NASH). Nuclear receptor PPARα (peroxisome proliferator-activated receptor α) has drawn special attention recently...
2.
Yu D, Huss J, Li H, Forman B
Bioorg Med Chem
. 2017 Feb;
25(5):1585-1599.
PMID: 28189393
Estrogen-related receptors (ERRs, α, β, and γ) are orphan nuclear receptors most closely related in sequence to estrogen receptors (ERα and ERβ). Much attention has been paid recently to the...
3.
Yu D, Andrali S, Li H, Lin M, Huang W, Forman B
Bioorg Med Chem
. 2016 Jul;
24(18):3986-3993.
PMID: 27372840
Metabolic disorders such as diabetes are known risk factors for developing cholesterol gallstone disease (CGD). Cholesterol gallstone disease is one of the most prevalent digestive diseases, leading to considerable financial...
4.
Yu D, Sousa K, Mattern D, Wagner J, Fu X, Vaidehi N, et al.
Bioorg Med Chem
. 2015 Mar;
23(7):1613-28.
PMID: 25735208
GP-BAR1 (also known as TGR5), a novel G-protein coupled receptor regulating various non-genomic functions via bile acid signaling, has emerged as a promising target for metabolic disorders, including obesity and...
5.
Yu D, Lin W, Forman B, Chen T
Bioorg Med Chem
. 2014 Apr;
22(11):2919-38.
PMID: 24775917
Farnesoid X receptor (FXR, NRIH4) plays a major role in the control of cholesterol metabolism. This suggests that antagonizing the transcriptional activity of FXR is a potential means to treat...
6.
Yu D, Lin W, Chen T, Forman B
Bioorg Med Chem
. 2013 May;
21(14):4266-78.
PMID: 23688559
FXR (farnesoid X receptor, NRIH4), a nuclear receptor, plays a major role in the control of cholesterol metabolism. FXR ligands have been investigated in preclinical studies for targeted therapy against...
7.
Gu L, Chen J, Synold T, Forman B, Kane S
J Pharmacol Exp Ther
. 2013 Mar;
345(3):438-45.
PMID: 23532932
The MDR1 gene encodes P-glycoprotein, a transmembrane drug efflux transporter that confers multidrug resistance in cancer cells and affects drug pharmacokinetics by virtue of its expression in the liver, kidney,...
8.
Yu D, Mattern D, Forman B
Steroids
. 2012 Sep;
77(13):1335-8.
PMID: 22999992
The active, potent, and selective Farnesoid X Receptor (FXR) agonist 6α-ethylchenodeoxycholic acid (6ECDCA) has been synthesized in improved yield compared to the published methodologies. The synthesis employed selective oxidation of...
9.
Chen W, Yu D, Forman B, Huang W, Wang Y
Hepatology
. 2012 Aug;
57(2):656-66.
PMID: 22911633
Unlabelled: Gpbar1 (TGR5), a membrane-bound bile acid receptor, is well known for its roles in regulation of energy homeostasis and glucose metabolism. TGR5 activation also inhibits nuclear factor κB (NF-κB)-mediated...
10.
Zhang L, Wang Y, Chen W, Wang X, Lou G, Liu N, et al.
Hepatology
. 2012 Jun;
56(6):2336-43.
PMID: 22711662
Unlabelled: Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily and is the primary bile acid receptor. We previously showed that FXR was required for the promotion...