Barbel Rohrer
Overview
Explore the profile of Barbel Rohrer including associated specialties, affiliations and a list of published articles.
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93
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7916
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Recent Articles
21.
Schnabolk G, Obert E, Banda N, Rohrer B
Invest Ophthalmol Vis Sci
. 2020 Dec;
61(14):11.
PMID: 33289791
Purpose: Age-related macular degeneration (AMD) shares similar risk factors and inflammatory responses with rheumatoid arthritis (RA). Previously, we identified increased risk for dry AMD among patients with RA compared to...
22.
Nicholson C, Ishii M, Annamalai B, Chandler K, Chwa M, Kenney M, et al.
Biochim Biophys Acta Gen Subj
. 2020 Nov;
1865(4):129798.
PMID: 33217521
Purpose: Extracellular vesicles (EVs) are predicted to represent the internal state of cells. In polarized RPE monolayers, EVs can mediate long-distance communication, requiring endocytosis via protein-protein interactions. EV uptake from...
23.
Annamalai B, Parsons N, Brandon C, Rohrer B
Mol Vis
. 2020 Jun;
26:370-377.
PMID: 32476817
Purpose: Risk for age-related macular degeneration (AMD), a slowly progressing, complex disease, is tied to an overactive complement system. Efforts are under way to develop an anticomplement-based treatment to be...
24.
Belhaj M, Annamalai B, Parsons N, Shuler A, Potts J, Rohrer B
J Vis Exp
. 2020 Apr;
(157).
PMID: 32281978
Many current therapeutics under development for diseases of the posterior pole of the eye are biologics. These drugs need to be administered frequently, typically via intravitreal injections. Encapsulated cells expressing...
25.
Annamalai B, Nicholson C, Parsons N, Stephenson S, Atkinson C, Jones B, et al.
Invest Ophthalmol Vis Sci
. 2020 Mar;
61(3):45.
PMID: 32207814
Purpose: Age-related macular degeneration (AMD) is the leading cause of blindness in Western populations. While an overactive complement system has been linked to pathogenesis, mechanisms contributing to its activation are...
26.
Nicholson C, Shah N, Ishii M, Annamalai B, Brandon C, Rodgers J, et al.
Biochim Biophys Acta Mol Basis Dis
. 2019 Nov;
1866(3):165608.
PMID: 31740401
Purpose: Extracellular vesicles (EVs) can mediate long-distance communication in polarized RPE monolayers. Specifically, EVs from oxidatively stressed donor cells (stress EVs) rapidly reduced barrier function (transepithelial resistance, TER) in naïve...
27.
Schnabolk G, Rohrer B, Simpson K
Invest Ophthalmol Vis Sci
. 2019 Aug;
60(10):3520-3526.
PMID: 31412111
Purpose: AMD is the leading cause of blindness in the United States. The role of secondary inflammatory disease on AMD progression is largely unknown. Here we investigate the association between...
28.
Ishii M, Beeson G, Beeson C, Rohrer B
Anal Biochem
. 2019 Apr;
577:52-58.
PMID: 31022379
Optimum cytosolic calcium concentrations support balanced mitochondrial respiration. However, cytosolic Ca concentrations vary among cell types and excess Ca can cause mitochondrial dysfunction. We optimized an isolation protocol to eliminate...
29.
Zuo X, Lobo G, Fulmer D, Guo L, Dang Y, Su Y, et al.
J Biol Chem
. 2019 Mar;
294(17):6710-6718.
PMID: 30824539
The exocyst is a highly conserved protein complex found in most eukaryotic cells and is associated with many functions, including protein translocation in the endoplasmic reticulum, vesicular basolateral targeting, and...
30.
Rohrer B, Frazer-Abel A, Leonard A, Ratnapriya R, Ward T, Pietraszkiewicz A, et al.
Mol Vis
. 2019 Mar;
25:79-92.
PMID: 30820144
Purpose: Smoking and the incidence of age-related macular degeneration (AMD) have been linked to an overactive complement system. Here, we examined in a retrospective cohort study whether AMD-associated single nucleotide...