Barbel Rohrer
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Explore the profile of Barbel Rohrer including associated specialties, affiliations and a list of published articles.
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93
Citations
7916
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Recent Articles
1.
Nair-Menon J, Kingsley C, Mesnaoui H, Lin P, Wilson K, Rohrer B, et al.
Res Sq
. 2025 Mar;
PMID: 40034449
The RNA interference (RNAi) machinery is a key cellular mechanism catalyzing biogenesis and function of miRNAs to post-transcriptionally regulate mRNA expression. The RNAi machinery includes a set of protein complexes...
2.
Wilson K, Holjencin C, Lee H, Annamalai B, Ishii M, Gilbert J, et al.
Mol Ther Nucleic Acids
. 2025 Feb;
36(1):102449.
PMID: 39991470
Gene therapy approaches for mitochondrial DNA (mtDNA)-associated damage/diseases have thus far been limited, and despite advancements in single gene therapy for mtDNA mutations and progress in mitochondrial transplantation, no method...
3.
Navneet S, Ishii M, Rohrer B
Invest Ophthalmol Vis Sci
. 2024 Jul;
65(8):34.
PMID: 39028977
Purpose: A single-nucleotide polymorphism in HTRA1 has been linked to age-related macular degeneration (AMD). Here we investigated the potential links between age-related retinal changes, elastin turnover, elastin autoantibody production, and...
4.
Navneet S, Wilson K, Rohrer B
Invest Ophthalmol Vis Sci
. 2024 Feb;
65(2):42.
PMID: 38416457
Müller glia, the main glial cell of the retina, are critical for neuronal and vascular homeostasis in the retina. During age-related macular degeneration (AMD) pathogenesis, Müller glial activation, remodeling, and...
5.
Parsons N, Annamalai B, Rohrer B
Transl Vis Sci Technol
. 2023 Jul;
12(7):17.
PMID: 37462980
Purpose: Risk for developing age-related macular degeneration (AMD) is linked to an overactive complement system. In the mouse model of laser-induced choroidal neovascularization (CNV), elevated levels of complement effector molecules,...
6.
Rohrer B, Parsons N, Annamalai B, Nicholson C, Obert E, Jones B, et al.
Adv Exp Med Biol
. 2023 Jul;
1415:67-71.
PMID: 37440016
Age-related macular degeneration (AMD) is associated with an overactive complement system and an increase in circulating antibodies. Our search for potential neoantigens that can trigger complement activation in disease has...
7.
Ishii M, Rohrer B
Biochim Biophys Acta Gen Subj
. 2023 May;
1867(8):130374.
PMID: 37187450
Mitochondrial dynamics is a morphological balance between fragmented and elongated shapes, reflecting mitochondrial metabolic status, cellular damage, and mitochondrial dysfunction. The anaphylatoxin C5a derived from complement component 5 cleavage, enhances...
8.
Navneet S, Brandon C, Simpson K, Rohrer B
Cells
. 2023 May;
12(9).
PMID: 37174708
Abnormal turnover of the extracellular matrix (ECM) protein elastin has been linked to AMD pathology. Elastin is a critical component of Bruch's membrane (BrM), an ECM layer that separates the...
9.
Obert E, Grek C, Ghatnekar G, Rohrer B
Heliyon
. 2022 Nov;
8(11):e11359.
PMID: 36387470
A critical target in age-related macular degeneration (AMD) is the retinal pigment epithelium (RPE), which forms the outer blood-retina barrier (BRB). RPE-barrier dysfunction might result from the disruption of intercellular...
10.
Alfaar A, Sturzbecher L, Diedrichs-Mohring M, Lam M, Roubeix C, Ritter J, et al.
J Neuroinflammation
. 2022 Oct;
19(1):260.
PMID: 36273134
Background: Forkhead-Box-Protein P3 (FoxP3) is a transcription factor and marker of regulatory T cells, converting naive T cells into Tregs that can downregulate the effector function of other T cells....