Barbara C Worst
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Explore the profile of Barbara C Worst including associated specialties, affiliations and a list of published articles.
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12
Citations
2347
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Recent Articles
1.
Clarke M, Mackay A, Ismer B, Pickles J, Tatevossian R, Newman S, et al.
Cancer Discov
. 2020 Apr;
10(7):942-963.
PMID: 32238360
Infant high-grade gliomas appear clinically distinct from their counterparts in older children, indicating that histopathologic grading may not accurately reflect the biology of these tumors. We have collected 241 cases...
2.
Jebessa Z, Shanmukha K, Dewenter M, Lehmann L, Xu C, Schreiter F, et al.
Nat Metab
. 2019 Nov;
1(11):1157-1167.
PMID: 31742248
Catecholamines stimulate the first step of lipolysis by PKA-dependent release of the lipid droplet-associated protein ABHD5 from perilipin to co-activate the lipase ATGL. Here, we unmask a yet unrecognized proteolytic...
3.
Pfaff E, El Damaty A, Balasubramanian G, Blattner-Johnson M, Worst B, Stark S, et al.
Eur J Cancer
. 2019 Apr;
114:27-35.
PMID: 31022591
Purpose: Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive paediatric brain tumour with fatal outcome. The Individualised Therapy For Relapsed Malignancies In Childhood (INFORM) registry study offers comprehensive molecular...
4.
Grobner S, Worst B, Weischenfeldt J, Buchhalter I, Kleinheinz K, Rudneva V, et al.
Nature
. 2018 Jun;
559(7714):E10.
PMID: 29875405
In this Article, author Benedikt Brors was erroneously associated with affiliation number '8' (Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, Tennessee, USA); the author's two other affiliations...
5.
Grobner S, Worst B, Weischenfeldt J, Buchhalter I, Kleinheinz K, Rudneva V, et al.
Nature
. 2018 Mar;
555(7696):321-327.
PMID: 29489754
Pan-cancer analyses that examine commonalities and differences among various cancer types have emerged as a powerful way to obtain novel insights into cancer biology. Here we present a comprehensive analysis...
6.
Northcott P, Buchhalter I, Morrissy A, Hovestadt V, Weischenfeldt J, Ehrenberger T, et al.
Nature
. 2017 Jul;
547(7663):311-317.
PMID: 28726821
Current therapies for medulloblastoma, a highly malignant childhood brain tumour, impose debilitating effects on the developing child, and highlight the need for molecularly targeted treatments with reduced toxicity. Previous studies...
7.
Liu K, Pajtler K, Worst B, Pfister S, Wechsler-Reya R
Sci Signal
. 2017 Mar;
10(470).
PMID: 28292958
Brain tumors are among the leading causes of cancer-related deaths in children. Although surgery, aggressive radiation, and chemotherapy have improved outcomes, many patients still die of their disease. Moreover, those...
8.
Worst B, van Tilburg C, Balasubramanian G, Fiesel P, Witt R, Freitag A, et al.
Eur J Cancer
. 2016 Aug;
65:91-101.
PMID: 27479119
The 'Individualized Therapy for Relapsed Malignancies in Childhood' (INFORM) precision medicine study is a nationwide German program for children with high-risk relapsed/refractory malignancies, which aims to identify therapeutic targets on...
9.
Sturm D, Orr B, Toprak U, Hovestadt V, Jones D, Capper D, et al.
Cell
. 2016 Feb;
164(5):1060-1072.
PMID: 26919435
Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly aggressive, poorly differentiated embryonal tumors occurring predominantly in young children but also affecting adolescents and adults. Herein, we demonstrate...
10.
Lin C, Erkek S, Tong Y, Yin L, Federation A, Zapatka M, et al.
Nature
. 2016 Jan;
530(7588):57-62.
PMID: 26814967
Medulloblastoma is a highly malignant paediatric brain tumour, often inflicting devastating consequences on the developing child. Genomic studies have revealed four distinct molecular subgroups with divergent biology and clinical behaviour....