Axel J Scheidig
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Explore the profile of Axel J Scheidig including associated specialties, affiliations and a list of published articles.
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47
Citations
490
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Recent Articles
11.
Indorf P, Kubitza C, Scheidig A, Kunze T, Clement B
J Med Chem
. 2019 Dec;
63(12):6538-6546.
PMID: 31790578
For the development of new drugs, the investigation of their metabolism is of central importance. In the past, the focus was mostly on the consideration of established enzymes leading to...
12.
Bartels A, Gottert S, Desel C, Schafer M, Krossa S, Scheidig A, et al.
Cell Physiol Biochem
. 2019 Apr;
52(4):850-868.
PMID: 30958660
Background/aims: Endoplasmic reticulum (ER)-resident proteins with a C-terminal KDEL ERretention sequence are captured in the Golgi apparatus by KDEL receptors (KDELRs). The binding of such proteins to these receptors induces...
13.
Zhang R, Zhang N, Mohri M, Wu L, Eckert T, Krylov V, et al.
ACS Omega
. 2019 Mar;
4(2):4206-4220.
PMID: 30847433
Insulin and lysozyme share the common features of being prone to aggregate and having biomedical importance. Encapsulating lysozyme and insulin in micellar nanoparticles probably would prevent aggregation and facilitate oral...
14.
Kubitza C, Bittner F, Ginsel C, Havemeyer A, Clement B, Scheidig A
Proc Natl Acad Sci U S A
. 2018 Nov;
115(47):11958-11963.
PMID: 30397129
Biotransformation enzymes ensure a viable homeostasis by regulating reversible cycles of oxidative and reductive reactions. The metabolism of nitrogen-containing compounds is of high pharmaceutical and toxicological relevance because N-oxygenated metabolites...
15.
Ginsel C, Plitzko B, Froriep D, Stolfa D, Jung M, Kubitza C, et al.
Drug Metab Dispos
. 2018 Jul;
46(10):1396-1402.
PMID: 30045842
The mitochondrial amidoxime reducing component is a recently discovered molybdenum enzyme in mammals which, in concert with the electron transport proteins cytochrome b5 and NADH cytochrome b5 reductase, catalyzes the...
16.
Kubitza C, Ginsel C, Bittner F, Havemeyer A, Clement B, Scheidig A
Acta Crystallogr F Struct Biol Commun
. 2018 Jun;
74(Pt 6):337-344.
PMID: 29870017
The human mitochondrial amidoxime reducing component (hmARC) is a molybdenum cofactor-dependent enzyme that is involved in the reduction of a diverse range of N-hydroxylated compounds of either physiological or xenobiotic...
17.
Kubitza C, Faust A, Gutt M, Gath L, Ober D, Scheidig A
Acta Crystallogr D Struct Biol
. 2018 May;
74(Pt 5):422-432.
PMID: 29717713
The high-resolution crystal structure of the flavin-dependent monooxygenase (FMO) from the African locust Zonocerus variegatus is presented and the kinetics of structure-based protein variants are discussed. Z. variegatus expresses three...
18.
Owen D, Alexandrov K, Rostkova E, Scheidig A, Goody R, Waldmann H
Angew Chem Int Ed Engl
. 2018 May;
38(4):509-512.
PMID: 29711783
The N-methylanthraniloylisoprenoid diphosphate derivatives 1 and 2 bind to RabGGTase II and are enzymatically transferred to Rab 7 (the Rab proteins are small G-proteins that control events of docking and...
19.
Krossa S, Scheidig A, Grotzinger J, Lorenzen I
Sci Rep
. 2018 Jan;
8(1):1103.
PMID: 29348576
A Disintegrin and Metalloprotease 17 (ADAM17) can cause the fast release of growth factors and inflammatory mediators from the cell surface. Its activity has to be turned on which occurs...
20.
Zhang R, Wu L, Eckert T, Burg-Roderfeld M, Rojas-Macias M, Lutteke T, et al.
Q Rev Biophys
. 2017 Dec;
50:e9.
PMID: 29233221
Interactions between human lysozyme (HL) and the lipopolysaccharide (LPS) of Klebsiella pneumoniae O1, a causative agent of lung infection, were identified by surface plasmon resonance. To characterize the molecular mechanism...