Michel A Struwe
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Explore the profile of Michel A Struwe including associated specialties, affiliations and a list of published articles.
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9
Citations
21
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Recent Articles
1.
Klopp C, Zhang X, Campbell M, Kvaskoff D, Struwe M, Warren C, et al.
J Med Chem
. 2024 Oct;
67(20):18090-18097.
PMID: 39397364
-Hydroxyurea has been known since the 1960s as an antiproliferative drug and is used both in oncology and for treatment of hematological disorders such as sickle cell anemia where very...
2.
Struwe M, Yang J, Kolanji K, Mengell J, Scheidig A, Clement B, et al.
Inorg Chem
. 2024 Oct;
63(41):19063-19073.
PMID: 39350518
A combination of X-ray absorption and low-temperature electronic absorption spectroscopies has been used to probe the geometric and electronic structures of the human mitochondrial amidoxime reducing component enzyme (hmARC1) in...
3.
Jones A, Bajrami B, Campbell M, Erzurumluoglu A, Guo Q, Chen H, et al.
Hepatol Commun
. 2024 Apr;
8(5).
PMID: 38619429
Background: Mutations in the gene MTARC1 (mitochondrial amidoxime-reducing component 1) protect carriers from metabolic dysfunction-associated steatohepatitis (MASH) and cirrhosis. MTARC1 encodes the mARC1 enzyme, which is localized to the mitochondria...
4.
Struwe M, Scheidig A, Clement B
J Biol Chem
. 2023 Oct;
299(11):105306.
PMID: 37778733
The mitochondrial amidoxime-reducing component (mARC) is one of five known molybdenum enzymes in eukaryotes. mARC belongs to the MOSC domain superfamily, a large group of so far poorly studied molybdoenzymes....
5.
Rixen S, Indorf P, Kubitza C, Struwe M, Klopp C, Scheidig A, et al.
Molecules
. 2023 Sep;
28(17).
PMID: 37687214
The mitochondrial amidoxime reducing component (mARC) is a human molybdoenzyme known to catalyze the reduction of various -oxygenated substrates. The physiological function of mARC enzymes, however, remains unknown. In this...
6.
Klopp C, Struwe M, Plieth C, Clement B, Scheidig A
Anal Chem
. 2023 Aug;
95(33):12452-12458.
PMID: 37549068
The mitochondrial amidoxime-reducing component (mARC) is one of the simplest molybdenum-containing enzymes. mARC is among a few known reducing enzymes playing an important role in drug metabolism in mammals. Here,...
7.
Clement B, Struwe M
Molecules
. 2023 Jun;
28(12).
PMID: 37375270
The mitochondrial amidoxime-reducing component (mARC) is the most recently discovered molybdoenzyme in humans after sulfite oxidase, xanthine oxidase and aldehyde oxidase. Here, the timeline of mARC's discovery is briefly described....
8.
Struwe M, Clement B, Scheidig A
Hepatol Commun
. 2022 May;
6(11):3277-3278.
PMID: 35560545
A study recently published in Hepatology Communications provided insights into a variant of MTARC1 protein, which conveys protection against liver disease. Here, we report a crystal structure of the variant...
9.
Struwe M, Kalimuthu P, Luo Z, Zhong Q, Ellis D, Yang J, et al.
J Biol Chem
. 2021 Apr;
296:100672.
PMID: 33887324
MtsZ is a molybdenum-containing methionine sulfoxide reductase that supports virulence in the human respiratory pathogen Haemophilus influenzae (Hi). HiMtsZ belongs to a group of structurally and spectroscopically uncharacterized S-/N-oxide reductases,...