Avinash Persaud
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Explore the profile of Avinash Persaud including associated specialties, affiliations and a list of published articles.
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19
Citations
813
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Recent Articles
1.
Liu Z, Demian W, Persaud A, Jiang C, Subramanaya A, Rotin D
Sci Rep
. 2022 Aug;
12(1):14480.
PMID: 36008477
p38-MAPK is a stress-response kinase activated by hyperosmolarity. Here we interrogated the pathways involved. We show that p38-MAPK signaling is activated by hyperosmotic stimulation in various solutions, cell types and...
2.
Persaud A, Jiang C, Liu Z, Kefalas G, Demian W, Rotin D
Proc Natl Acad Sci U S A
. 2022 Jul;
119(30):e2122495119.
PMID: 35858421
Regulation of catalytic activity of E3 ubiquitin ligases is critical for their cellular functions. We identified an unexpected mode of regulation of E3 catalytic activity by ions and osmolarity; enzymatic...
3.
Levin-Kravets O, Kordonsky A, Shusterman A, Biswas S, Persaud A, Elias S, et al.
J Mol Biol
. 2021 Oct;
433(23):167276.
PMID: 34599943
Split reporter protein-based genetic section systems are widely used to identify and characterize protein-protein interactions (PPI). The assembly of split markers that antagonize toxins, rather than required for synthesis of...
4.
Demian W, Persaud A, Jiang C, Coyaud E, Liu S, Kapus A, et al.
Cell Rep
. 2019 May;
27(6):1886-1896.e6.
PMID: 31067471
mTORC1 regulates cellular growth and is activated by growth factors and by essential amino acids such as Leu. Leu enters cells via the Leu transporter LAT1-4F2hc (LAT1). Here we show...
5.
Li Y, Duah E, Long N, Persaud A, VanGundy Z, Magliery T, et al.
Bioanalysis
. 2019 Mar;
11(6):471-483.
PMID: 30892061
To develop and validate a reliable, robust and efficient assay to detect and quantify biologic compounds and during early stage of a biotherapeutic agent discovery. An enrichment-free immunoassay method was...
6.
Wasserman S, Shteiman-Kotler A, Harris K, Iliadi K, Persaud A, Zhong Y, et al.
J Biol Chem
. 2018 Dec;
294(5):1739-1752.
PMID: 30518551
Nedd4 (dNedd4) is a HECT E3 ubiquitin ligase present in two major isoforms: short (dNedd4S) and long (dNedd4Lo), with the latter containing two unique regions (N terminus and Middle). Although...
7.
Levin-Kravets O, Keren-Kaplan T, Attali I, Sharon I, Tanner N, Shapira D, et al.
Methods Mol Biol
. 2018 Sep;
1844:155-166.
PMID: 30242709
Ubiquitylation is an eukaryotic signal that regulates most cellular pathways. However, four major hurdles pose challenges to study ubiquitylation: (1) high redundancy between ubiquitin (Ub) cascades, (2) ubiquitylation is tightly...
8.
Persaud A, Cormerais Y, Pouyssegur J, Rotin D
J Cell Sci
. 2017 Nov;
131(1).
PMID: 29150487
mTORC1 plays a crucial role in protein synthesis and cell proliferation and growth. It is activated by growth factors and amino acids, including essential amino acids (EAAs), such as leucine;...
9.
Attali I, Tobelaim W, Persaud A, Motamedchaboki K, Simpson-Lavy K, Mashahreh B, et al.
EMBO J
. 2017 Jan;
36(4):425-440.
PMID: 28069708
Ubiquitylation controls protein function and degradation. Therefore, ubiquitin ligases need to be tightly controlled. We discovered an evolutionarily conserved allosteric restraint mechanism for Nedd4 ligases and demonstrated its function with...
10.
Zhang W, Wu K, Sartori M, Kamadurai H, Ordureau A, Jiang C, et al.
Mol Cell
. 2016 Mar;
62(1):121-36.
PMID: 26949039
HECT-family E3 ligases ubiquitinate protein substrates to control virtually every eukaryotic process and are misregulated in numerous diseases. Nonetheless, understanding of HECT E3s is limited by a paucity of selective...