Avinash Persaud
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Explore the profile of Avinash Persaud including associated specialties, affiliations and a list of published articles.
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19
Citations
813
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Recent Articles
11.
Milkereit R, Persaud A, VAnoaica L, Guetg A, Verrey F, Rotin D
Nat Commun
. 2015 May;
6:7250.
PMID: 25998567
Mammalian target of rapamycin 1 (mTORC1), a master regulator of cellular growth, is activated downstream of growth factors, energy signalling and intracellular essential amino acids (EAAs) such as Leu. mTORC1...
12.
Fang N, Chan G, Zhu M, Comyn S, Persaud A, Deshaies R, et al.
Nat Cell Biol
. 2014 Oct;
16(12):1227-37.
PMID: 25344756
The heat-shock response is a complex cellular program that induces major changes in protein translation, folding and degradation to alleviate toxicity caused by protein misfolding. Although heat shock has been...
13.
Persaud A, Alberts P, Mari S, Tong J, Murchie R, Maspero E, et al.
Sci Signal
. 2014 Oct;
7(346):ra95.
PMID: 25292214
Ligand binding to the receptor tyrosine kinase fibroblast growth factor (FGF) receptor 1 (FGFR1) causes dimerization and activation by transphosphorylation of tyrosine residues in the kinase domain. FGFR1 is ubiquitylated...
14.
Murchie R, Guo C, Persaud A, Muise A, Rotin D
Proc Natl Acad Sci U S A
. 2014 Jan;
111(2):693-8.
PMID: 24385580
Protein tyrosine phosphatase (PTP)σ (PTPRS) was shown previously to be associated with susceptibility to inflammatory bowel disease (IBD). PTPσ(-/-) mice exhibit an IBD-like phenotype in the intestine and show increased...
15.
Beck J, Maerki S, Posch M, Metzger T, Persaud A, Scheel H, et al.
Nat Cell Biol
. 2013 Mar;
15(4):430-9.
PMID: 23455478
Polo-like kinase 1 (PLK1) critically regulates mitosis through its dynamic localization to kinetochores, centrosomes and the midzone. The polo-box domain (PBD) and activity of PLK1 mediate its recruitment to mitotic...
16.
Ernst A, Avvakumov G, Tong J, Fan Y, Zhao Y, Alberts P, et al.
Science
. 2013 Jan;
339(6119):590-5.
PMID: 23287719
The ubiquitin system regulates virtually all aspects of cellular function. We report a method to target the myriad enzymes that govern ubiquitination of protein substrates. We used massively diverse combinatorial...
17.
Persaud A, Rotin D
Methods Mol Biol
. 2011 Aug;
759:215-24.
PMID: 21863490
Ubiquitin-protein ligases (E3s) are responsible for target recognition and subsequent modification of selected substrates within the ubiquitin proteasomal system (UPS). Substrates of this pathway are covalently modified by the attachment...
18.
Persaud A, Alberts P, Hayes M, Guettler S, Clarke I, Sicheri F, et al.
EMBO J
. 2011 Jul;
30(16):3259-73.
PMID: 21765395
Fibroblast growth factor receptor 1 (FGFR1) has critical roles in cellular proliferation and differentiation during animal development and adult homeostasis. Here, we show that human Nedd4 (Nedd4-1), an E3 ubiquitin...
19.
Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays
Persaud A, Alberts P, Amsen E, Xiong X, Wasmuth J, Saadon Z, et al.
Mol Syst Biol
. 2009 Dec;
5:333.
PMID: 19953087
Target recognition by the ubiquitin system is mediated by E3 ubiquitin ligases. Nedd4 family members are E3 ligases comprised of a C2 domain, 2-4 WW domains that bind PY motifs...