Atesh K Worthington
Overview
Explore the profile of Atesh K Worthington including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
153
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0
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Recent Articles
1.
Poscablo D, Worthington A, Smith-Berdan S, Rommel M, Manso B, Adili R, et al.
Cell
. 2024 May;
187(12):3090-3107.e21.
PMID: 38749423
Platelet dysregulation is drastically increased with advanced age and contributes to making cardiovascular disorders the leading cause of death of elderly humans. Here, we reveal a direct differentiation pathway from...
2.
Martin E, Rodriguez Y Baena A, Reggiardo R, Worthington A, Mattingly C, Poscablo D, et al.
Stem Cells
. 2023 Mar;
41(5):520-539.
PMID: 36945732
Epigenetic mechanisms regulate the multilineage differentiation capacity of hematopoietic stem cells (HSCs) into a variety of blood and immune cells. Mapping the chromatin dynamics of functionally defined cell populations will...
3.
Johnson K, Yang C, Carter J, Worthington A, Robinson E, Lopez-Magana R, et al.
Infect Immun
. 2022 Dec;
91(1):e0032222.
PMID: 36533917
Helicobacter pylori colonizes half of the world's population and is responsible for a significant disease burden by causing gastritis, peptic ulcers, and gastric cancer. The development of host inflammation drives...
4.
Baudin P, Sacksteder R, Worthington A, Voitiuk K, T Ly V, Hoffman R, et al.
Heliyon
. 2022 Nov;
8(11):e11596.
PMID: 36439758
Project-based learning (PBL) has long been recognized as an effective way to teach complex biology concepts. However, not all institutions have the resources to facilitate effective project-based coursework for students....
5.
Worthington A, Forsberg E
Am J Hematol
. 2022 May;
97(9):1226-1235.
PMID: 35560111
Clustered regularly interspaced short palindromic repeats (CRISPR)/Cas genome engineering has emerged as a powerful tool to modify precise genomic sequences with unparalleled accuracy and efficiency. Major advances in CRISPR technologies...
6.
Worthington A, Cool T, Poscablo D, Hussaini A, Beaudin A, Forsberg E
Development
. 2022 Jan;
149(8).
PMID: 35072209
Tissue-resident lymphoid cells (TLCs) span the spectrum of innate-to-adaptive immune function. Unlike traditional, circulating lymphocytes that are continuously generated from hematopoietic stem cells (HSCs), many TLCs are of fetal origin...
7.
Poscablo D, Worthington A, Smith-Berdan S, Forsberg E
Stem Cell Reports
. 2021 May;
16(6):1598-1613.
PMID: 34019813
Age-related morbidity is associated with a decline in hematopoietic stem cell (HSC) function, but the mechanisms of HSC aging remain unclear. We performed heterochronic HSC transplants followed by quantitative analysis...
8.
Burrus C, McKinstry S, Kim N, Ozlu M, Santoki A, Fang F, et al.
Cell Rep
. 2020 Jan;
30(3):642-657.e6.
PMID: 31968243
Huntington's disease (HD) is caused by an autosomal dominant polyglutamine expansion mutation of Huntingtin (HTT). HD patients suffer from progressive motor, cognitive, and psychiatric impairments, along with significant degeneration of...
9.
McKinstry S, Karadeniz Y, Worthington A, Hayrapetyan V, Ozlu M, Serafin-Molina K, et al.
J Neurosci
. 2014 Jul;
34(28):9455-72.
PMID: 25009276
Huntington's disease (HD) is a neurodegenerative disease caused by the expansion of a poly-glutamine (poly-Q) stretch in the huntingtin (Htt) protein. Gain-of-function effects of mutant Htt have been extensively investigated...