Stephanie Smith-Berdan
Overview
Explore the profile of Stephanie Smith-Berdan including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
669
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0
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Recent Articles
1.
Manso B, Medina P, Smith-Berdan S, Rodriguez Y Baena A, Bachinsky E, Mok L, et al.
bioRxiv
. 2024 Nov;
PMID: 39574585
Distinct routes of cellular production from hematopoietic stem cells (HSCs) have defined our current view of hematopoiesis. Recently, we challenged classical views of platelet generation, demonstrating that megakaryocyte progenitors (MkPs),...
2.
Poscablo D, Worthington A, Smith-Berdan S, Rommel M, Manso B, Adili R, et al.
Cell
. 2024 May;
187(12):3090-3107.e21.
PMID: 38749423
Platelet dysregulation is drastically increased with advanced age and contributes to making cardiovascular disorders the leading cause of death of elderly humans. Here, we reveal a direct differentiation pathway from...
3.
Smith-Berdan S, Bercasio A, Kramer L, Petkus B, Hinck L, Forsberg E
PLoS One
. 2021 Aug;
16(8):e0255606.
PMID: 34388149
Hematopoietic stem cell (HSC) trafficking is regulated by a number of complex mechanisms. Among them are the transmembrane protein Robo4 and the vascular cell adhesion molecule, VCAM1. Endothelial VCAM1 is...
4.
Poscablo D, Worthington A, Smith-Berdan S, Forsberg E
Stem Cell Reports
. 2021 May;
16(6):1598-1613.
PMID: 34019813
Age-related morbidity is associated with a decline in hematopoietic stem cell (HSC) function, but the mechanisms of HSC aging remain unclear. We performed heterochronic HSC transplants followed by quantitative analysis...
5.
Rajendiran S, Smith-Berdan S, Kunz L, Risolino M, Selleri L, Schroeder T, et al.
Stem Cells
. 2020 May;
38(9):1159-1174.
PMID: 32442338
C-X-C motif chemokine ligand 12 (CXCL12; aka SDF1α) is a major regulator of a number of cellular systems, including hematopoiesis, where it influences hematopoietic cell trafficking, proliferation, and survival during...
6.
Smith-Berdan S, Bercasio A, Rajendiran S, Forsberg E
Stem Cell Reports
. 2019 Oct;
13(5):787-792.
PMID: 31607567
Hematopoietic stem cell (HSC) transplantation is a curative treatment for a variety of blood and immune disorders. Currently available methods to obtain donor HSCs are suboptimal, and the limited supply...
7.
Boyer S, Rajendiran S, Beaudin A, Smith-Berdan S, Muthuswamy P, Perez-Cunningham J, et al.
Stem Cell Reports
. 2019 Mar;
12(4):801-815.
PMID: 30905737
Hematopoiesis is arguably one of the best understood stem cell systems; however, significant challenges remain to reach a consensus understanding of the lineage potential, heterogeneity, and relationships of hematopoietic stem...
8.
Domen J, Christensen J, Gille D, Smith-Berdan S, Fong T, Brown J, et al.
Cell Transplant
. 2015 Mar;
25(1):17-33.
PMID: 25812169
Severe neutropenia induced by chemotherapy or conditioning for hematopoietic cell transplantation often results in morbidity and mortality due to infection by opportunistic pathogens. A system has been developed to generate...
9.
Smith-Berdan S, Nguyen A, Hong M, Forsberg E
Stem Cell Reports
. 2015 Feb;
4(2):255-68.
PMID: 25640759
Despite the use of hematopoietic stem cells (HSCs) in clinical therapy for over half a century, the mechanisms that regulate HSC trafficking, engraftment, and life-long persistence after transplantation are unclear....
10.
Smith-Berdan S, Schepers K, Ly A, Passegue E, Forsberg E
Cell Cycle
. 2012 Feb;
11(4):675-82.
PMID: 22313734
The bone marrow (BM) niche is essential for lifelong hematopoietic stem cell (HSC) maintenance, proliferation and differentiation. Several BM cell types, including osteoblast lineage cells (OBC), mesenchymal stem cells (MSC)...