Asa Karlstrom
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Explore the profile of Asa Karlstrom including associated specialties, affiliations and a list of published articles.
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16
Citations
897
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Recent Articles
1.
Patel A, Ashenberg O, Collins N, Segerstolpe A, Jiang S, Slyper M, et al.
bioRxiv
. 2024 Jan;
PMID: 38260392
Neuroblastoma is a pediatric cancer arising from the developing sympathoadrenal lineage with complex inter- and intra-tumoral heterogeneity. To chart this complexity, we generated a comprehensive cell atlas of 55 neuroblastoma...
2.
Patel A, Chen X, Huang X, Clay M, Komorova N, Krasin M, et al.
Dev Cell
. 2022 Apr;
57(10):1226-1240.e8.
PMID: 35483358
Rhabdomyosarcoma (RMS) is a pediatric cancer with features of skeletal muscle; patients with unresectable or metastatic RMS fare poorly due to high rates of disease recurrence. Here, we use single-cell...
3.
Slyper M, Porter C, Ashenberg O, Waldman J, Drokhlyansky E, Wakiro I, et al.
Nat Med
. 2020 Jun;
26(8):1307.
PMID: 32587393
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
4.
Slyper M, Porter C, Ashenberg O, Waldman J, Drokhlyansky E, Wakiro I, et al.
Nat Med
. 2020 May;
26(5):792-802.
PMID: 32405060
Single-cell genomics is essential to chart tumor ecosystems. Although single-cell RNA-Seq (scRNA-Seq) profiles RNA from cells dissociated from fresh tumors, single-nucleus RNA-Seq (snRNA-Seq) is needed to profile frozen or hard-to-dissociate...
5.
Loh A, Stewart E, Bradley C, Chen X, Daryani V, Stewart C, et al.
Cancer Lett
. 2018 Nov;
442:262-270.
PMID: 30395907
Lead discovery in osteosarcoma has been hampered by the lack of new agents, limited representative clinical samples and paucity of accurate preclinical models. We developed orthotopic patient-derived xenografts (PDXs) that...
6.
Stewart E, Federico S, Chen X, Shelat A, Bradley C, Gordon B, et al.
Nature
. 2017 Aug;
549(7670):96-100.
PMID: 28854174
Paediatric solid tumours arise from endodermal, ectodermal, or mesodermal lineages. Although the overall survival of children with solid tumours is 75%, that of children with recurrent disease is below 30%....
7.
Stewart E, Federico S, Karlstrom A, Shelat A, Sablauer A, Pappo A, et al.
Dev Biol
. 2015 Jun;
411(2):287-293.
PMID: 26068307
Significant advances have been made over the past 25 years in our understanding of the most common adult solid tumors such as breast, colon, lung and prostate cancer. Much less...
8.
Gupte A, Baker E, Wan S, Stewart E, Loh A, Shelat A, et al.
Clin Cancer Res
. 2015 Apr;
21(14):3216-29.
PMID: 25862761
Purpose: Osteosarcoma is the most common cancer of bone occurring mostly in teenagers. Despite rapid advances in our knowledge of the genetics and cell biology of osteosarcoma, significant improvements in...
9.
Stewart E, Goshorn R, Bradley C, Griffiths L, Benavente C, Twarog N, et al.
Cell Rep
. 2014 Dec;
9(3):829-41.
PMID: 25437539
Ewing sarcoma (EWS) is a tumor of the bone and soft tissue that primarily affects adolescents and young adults. With current therapies, 70% of patients with localized disease survive, but...
10.
Karlstrom A, Heston S, Boyd K, Tuomanen E, McCullers J
J Infect Dis
. 2011 Sep;
204(9):1358-66.
PMID: 21900488
Host inflammatory responses contribute to the significant immunopathology that occurs during treatment of secondary bacterial pneumonia following influenza. We undertook the present study to determine the mechanisms underlying disparate outcomes...