Anurag Purushothaman
Overview
Explore the profile of Anurag Purushothaman including associated specialties, affiliations and a list of published articles.
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21
Citations
1201
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Recent Articles
1.
Siqueira J, Mitani Y, Hoff C, Bonini F, De Sousa L, Marques-Piubelli M, et al.
Mod Pathol
. 2023 Nov;
37(1):100371.
PMID: 38015043
B7-H4 (VTCN1), a member of the B7 family, is overexpressed in several types of cancer. Here we investigated the pattern of expression of B7-H4 in salivary gland carcinomas (SGC) and...
2.
Purushothaman A, Oliva-Ramirez J, Treekitkarnmongkol W, Sankaran D, Hurd M, Putluri N, et al.
Int J Mol Sci
. 2023 Oct;
24(19).
PMID: 37834100
Pancreatic ductal adenocarcinoma (PDAC) cells display extensive crosstalk with their surrounding environment to regulate tumor growth, immune evasion, and metastasis. Recent advances have attributed many of these interactions to intercellular...
3.
Purushothaman A, Mohajeri M, Lele T
J Biol Chem
. 2023 Jan;
299(3):102935.
PMID: 36693448
Although cancer is a genetic disease, physical changes such as stiffening of the extracellular matrix also commonly occur in cancer. Cancer cells sense and respond to extracellular matrix stiffening through...
4.
Purushothaman A, Sanderson R
Adv Exp Med Biol
. 2020 Apr;
1221:331-349.
PMID: 32274716
It has been speculated for many years that heparanase plays an important role in the progression of cancer due largely to the finding that its expression is weak or absent...
5.
Exosomes from Cell Culture-Conditioned Medium: Isolation by Ultracentrifugation and Characterization
Purushothaman A
Methods Mol Biol
. 2019 Mar;
1952:233-244.
PMID: 30825179
Exosomes are small vesicles of endosomal origin secreted by most cell types. Recent studies have identified exosomes as important mediators of intercellular communication and as important source materials for many...
6.
Purushothaman A, Bandari S, Chandrashekar D, Jones R, Lee H, Weber D, et al.
Oncotarget
. 2017 Nov;
8(43):73723-73732.
PMID: 29088739
Tumor cells produce and utilize exosomes to promote tumor growth and metastasis. Tumor-cell-derived exosomes deliver cargos that partially mimic the contents of the parent cell to nearby or distant normal...
7.
Bandari S, Purushothaman A, Ramani V, Brinkley G, Chandrashekar D, Varambally S, et al.
Matrix Biol
. 2017 Sep;
65:104-118.
PMID: 28888912
Summary: We find that anti-myeloma chemotherapy dramatically stimulates secretion of exosomes and alters exosome composition. Exosomes secreted during therapy contain high levels of heparanase on their surface that can degrade...
8.
Purushothaman A, Bandari S, Liu J, Mobley J, Brown E, Sanderson R
J Biol Chem
. 2015 Nov;
291(4):1652-1663.
PMID: 26601950
Exosomes regulate cell behavior by binding to and delivering their cargo to target cells; however, the mechanisms mediating exosome-cell interactions are poorly understood. Heparan sulfates on target cell surfaces can...
9.
Yoshida C, Kawane T, Moriishi T, Purushothaman A, Miyazaki T, Komori H, et al.
J Biol Chem
. 2014 Aug;
289(38):26584-26596.
PMID: 25107907
Galnt3, UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3, transfers N-acetyl-D-galactosamine to serine and threonine residues, initiating mucin type O-glycosylation of proteins. We searched the target genes of Runx2, which is an essential transcription factor...
10.
Purushothaman A, Toole B
J Biol Chem
. 2014 Jan;
289(9):5499-509.
PMID: 24403068
Recently, it was discovered that serglycin, a hematopoietic cell proteoglycan, is the major proteoglycan expressed and constitutively secreted by multiple myeloma (MM) cells. High levels of serglycin are present in...