Anu Mahadevan
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Explore the profile of Anu Mahadevan including associated specialties, affiliations and a list of published articles.
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Citations
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Recent Articles
11.
Batkai S, Mukhopadhyay P, Horvath B, Rajesh M, Gao R, Mahadevan A, et al.
Br J Pharmacol
. 2011 Apr;
165(8):2450-61.
PMID: 21470208
Background And Purpose: Activation of cannabinoid CB(2) receptors protects against various forms of ischaemia-reperfusion (I/R) injury. Δ(8) -Tetrahydrocannabivarin (Δ(8) -THCV) is a synthetic analogue of the plant cannabinoid Δ(9) -tetrahydrocannabivarin,...
12.
Wiley J, Breivogel C, Mahadevan A, Pertwee R, Cascio M, Bolognini D, et al.
Eur J Pharmacol
. 2010 Dec;
651(1-3):96-105.
PMID: 21114999
Rimonabant, the prototypic antagonist of cannabinoid CB(1) receptors, has been reported to have inverse agonist properties at higher concentrations, which may complicate its use as a tool for mechanistic evaluation...
13.
Kinsey S, Mahadevan A, Zhao B, Sun H, Naidu P, Razdan R, et al.
Neuropharmacology
. 2010 Sep;
60(2-3):244-51.
PMID: 20849866
Although Δ(9)-tetrahydrocannabinol (THC) and other mixed CB(1)/CB(2) receptor agonists are well established to elicit antinociceptive effects, their psychomimetic actions and potential for abuse have dampened enthusiasm for their therapeutic development....
14.
Booker L, Naidu P, Razdan R, Mahadevan A, Lichtman A
Drug Alcohol Depend
. 2009 Aug;
105(1-2):42-7.
PMID: 19679411
Considerable preclinical research has demonstrated the efficacy of Delta(9)-tetrahydrocannabinol (Delta(9)-THC), the primary psychoactive constituent of Cannabis sativa, in a wide variety of animal models of pain, but few studies have...
15.
Bisogno T, Burston J, Rai R, Allara M, Saha B, Mahadevan A, et al.
ChemMedChem
. 2009 Mar;
4(6):946-50.
PMID: 19266526
Biosynthesis Inhibition: O-5596, a new inhibitor of the biosynthesis of the endocannabinoid, 2-arachidonoylglycerol, was synthesized and found to be potent (IC(50)=100 nM) and selective versus other proteins and enzymes of...
16.
Burston J, Sim-Selley L, Harloe J, Mahadevan A, Razdan R, Selley D, et al.
J Pharmacol Exp Ther
. 2008 Aug;
327(2):546-53.
PMID: 18682568
Inhibition of the metabolism of the endocannabinoids, anandamide (AEA) and 2-arachidonyl glycerol (2-AG), by their primary metabolic enzymes, fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), respectively, has the...
17.
Bourne C, Roy S, Wiley J, Martin B, Thomas B, Mahadevan A, et al.
Bioorg Med Chem
. 2007 Sep;
15(24):7850-64.
PMID: 17827022
The structure-activity relationship (SAR) of the end pentyl chain in anandamide (AEA) has been established to be very similar to that of Delta(9)-tetrahydrocannabinol (Delta(9)-THC). In order to broaden our understanding...
18.
Liu J, Wang L, Harvey-White J, Huang B, Kim H, Luquet S, et al.
Neuropharmacology
. 2007 Jul;
54(1):1-7.
PMID: 17631919
Endocannabinoids, including anandamide (arachidonoyl ethanolamide) have been implicated in the regulation of a growing number of physiological and pathological processes. Anandamide can be generated from its membrane phospholipid precursor N-arachidonoyl...
19.
Crocker P, Mahadevan A, Wiley J, Martin B, Razdan R
Bioorg Med Chem Lett
. 2007 Jan;
17(6):1504-7.
PMID: 17257842
A facile synthesis of 1-fluoro-1-deoxy-Delta(8)-THC analogs with side chains seven carbons in length, in the alkane/ene/yne- series (6, 5, and 4), was achieved from 1-fluoro-3,5-dimethoxybenzene (1). In vitro studies show...
20.
Martin B, Wiley J, Beletskaya I, Sim-Selley L, Smith F, Dewey W, et al.
J Pharmacol Exp Ther
. 2006 Jun;
318(3):1230-9.
PMID: 16757541
Presently, there are numerous structural classes of cannabinoid receptor agonists, all of which require solubilization for experimental purposes. One strategy for solubilizing water-insoluble tetrahydrocannabinols is conversion of the phenolic hydroxyl...