Antonio Macchiarulo
Overview
Explore the profile of Antonio Macchiarulo including associated specialties, affiliations and a list of published articles.
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Articles
151
Citations
3221
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Recent Articles
1.
Panfili E, Rezzi S, Adamo A, Mazzoletti D, Massarotti A, Miggiano R, et al.
ACS Pharmacol Transl Sci
. 2024 Oct;
7(10):3056-3070.
PMID: 39421661
Indoleamine 2,3-dioxygenase 1 (IDO1) plays a key role in tumor immune escape. Besides being a metabolic enzyme that catalyzes the first step of tryptophan catabolism, it also acts as a...
2.
Ballarotto M, Bianconi E, Valentini S, Temperini A, Moretti F, Macchiarulo A
Bioorg Med Chem
. 2024 Oct;
113:117937.
PMID: 39369567
In recent years, the restoration of p53 physiological functions has become an attractive therapeutic approach to develop novel and efficacious cancer therapies. Among other mechanisms, the oncosuppressor protein p53 is...
3.
Bigiotti C, Bianconi E, Ruta L, Grottelli S, Coletti A, Dindo M, et al.
J Chem Inf Model
. 2024 Aug;
64(17):6866-6879.
PMID: 39177258
Dimethylarginine dimethylaminohydrolase-1 (DDAH-1) accounts for the catabolism of the endogenous inhibitors of nitric oxide (NO) synthases, namely, ADMA (,-dimethyl-l-arginine) and NMMA (-monomethyl-l-arginine). Inhibition of DDAH-1 may prove a therapeutic benefit...
4.
Bonomini A, Felicetti T, Pacetti M, Bertagnin C, Coletti A, Giammarino F, et al.
Eur J Med Chem
. 2024 Aug;
277:116737.
PMID: 39153334
Influenza viruses (IV) are single-stranded RNA viruses with a negative-sense genome and have the potential to cause pandemics. While vaccines exist for influenza, their protection is only partial. Additionally, there...
5.
Zelante T, Paolicelli G, Fallarino F, Gargaro M, Vascelli G, De Zuani M, et al.
Sci Rep
. 2024 Mar;
14(1):6651.
PMID: 38509264
Multiple sclerosis is a debilitating autoimmune disease, characterized by chronic inflammation of the central nervous system. While the significance of the gut microbiome on multiple sclerosis pathogenesis is established, the...
6.
Desantis J, Bazzacco A, Eleuteri M, Tuci S, Bianconi E, Macchiarulo A, et al.
Eur J Med Chem
. 2024 Feb;
268:116202.
PMID: 38394929
To date, Proteolysis Targeting Chimera (PROTAC) technology has been successfully applied to mediate proteasomal-induced degradation of several pharmaceutical targets mainly related to oncology, immune disorders, and neurodegenerative diseases. On the...
7.
Rossini S, Ambrosino S, Volpi C, Belladonna M, Pallotta M, Panfili E, et al.
Front Immunol
. 2024 Feb;
15:1346686.
PMID: 38333210
The tryptophan-degrading enzyme indoleamine 2,3-dioxygenase 1 (IDO1) is a plastic immune checkpoint molecule that potently orchestrates immune responses within the tumor microenvironment (TME). As a heme-containing protein, IDO1 catalyzes the...
8.
Bianconi E, Gidari A, Souma M, Sabbatini S, Grifagni D, Bigiotti C, et al.
J Enzyme Inhib Med Chem
. 2023 Aug;
38(1):2251721.
PMID: 37638806
Non-structural protein 5 (Nsp5) is a cysteine protease that plays a key role in SARS-CoV-2 replication, suppressing host protein synthesis and promoting immune evasion. The investigation of natural products as...
9.
Carotti A, Varfaj I, Pruscini I, Abualzulof G, Mercolini L, Bianconi E, et al.
J Sep Sci
. 2023 Jul;
46(18):e2300346.
PMID: 37438993
A fast HPLC method was developed to study the hydrophobicity extent of pharmaceutically relevant molecular fragments. By this strategy, the reduced amount of sample available for physico-chemical evaluations in early-phase...
10.
Rossini S, Gargaro M, Scalisi G, Bianconi E, Ambrosino S, Panfili E, et al.
Elife
. 2023 Jun;
12.
PMID: 37387273
Src is a protein tyrosine kinase commonly activated downstream of transmembrane receptors and plays key roles in cell growth, migration, and survival signaling pathways. In conventional dendritic cells (cDCs), Src...