Antonia Sassmann
Overview
Explore the profile of Antonia Sassmann including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
486
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Recent Articles
1.
Ruiz de Azua I, Mancini G, Srivastava R, Aparisi Rey A, Cardinal P, Tedesco L, et al.
J Clin Invest
. 2017 Oct;
127(11):4148-4162.
PMID: 29035280
Dysregulated adipocyte physiology leads to imbalanced energy storage, obesity, and associated diseases, imposing a costly burden on current health care. Cannabinoid receptor type-1 (CB1) plays a crucial role in controlling...
2.
Gong H, An S, Sassmann A, Liu M, Mastej V, Mittal M, et al.
Stem Cell Reports
. 2016 Nov;
7(6):1050-1058.
PMID: 27866874
We studied the function of the G-protein-coupled receptor PAR1 in mediating the differentiation of mouse embryonic stem cells (mESCs) to endothelial cells (ECs) that are capable of inducing neovascularization. We...
3.
Illison J, Tian L, McClafferty H, Werno M, Chamberlain L, Leiss V, et al.
Diabetes
. 2016 Sep;
65(12):3621-3635.
PMID: 27605626
Elevated adipose tissue expression of the Ca- and voltage-activated K (BK) channel was identified in morbidly obese men carrying a BK gene variant, supporting the hypothesis that K channels affect...
4.
Mitschke M, Hoffmann L, Gnad T, Scholz D, Kruithoff K, Mayer P, et al.
FASEB J
. 2013 Jan;
27(4):1621-30.
PMID: 23303211
With more than half a billion individuals affected worldwide, obesity has reached pandemic proportions. Development of "brown-like" or "brite" adipocytes within white adipose tissue (WAT) has potential antiobesity and insulin-sensitizing...
5.
Sassmann A, Offermanns S, Wettschureck N
Genesis
. 2010 Aug;
48(10):618-25.
PMID: 20715175
To generate a mouse line which allows inducible, Cre/loxP-dependent recombination in adipocytes, we used RedE/RedT-mediated recombineering to insert the CreER(T)²-transgene, which encodes a fusion protein of Cre and a mutated...
6.
Sassmann A, Gier B, Grone H, Drews G, Offermanns S, Wettschureck N
J Clin Invest
. 2010 May;
120(6):2184-93.
PMID: 20440069
A variety of neurotransmitters, gastrointestinal hormones, and metabolic signals are known to potentiate insulin secretion through GPCRs. We show here that beta cell-specific inactivation of the genes encoding the G...
7.
Ahmed K, Tunaru S, Tang C, Muller M, Gille A, Sassmann A, et al.
Cell Metab
. 2010 Apr;
11(4):311-9.
PMID: 20374963
Lactate is an important metabolic intermediate released by skeletal muscle and other organs including the adipose tissue, which converts glucose into lactate under the influence of insulin. Here we show...
8.
Herroeder S, Reichardt P, Sassmann A, Zimmermann B, Jaeneke D, Hoeckner J, et al.
Immunity
. 2009 May;
30(5):708-20.
PMID: 19409815
Integrin-mediated adhesion plays a central role in T cell trafficking and activation. Genetic inactivation of the guanine nucleotide-binding (G) protein alpha-subunits Galpha(12) and Galpha(13) resulted in an increased activity of...
9.
Rieken S, Herroeder S, Sassmann A, Wallenwein B, Moers A, Offermanns S, et al.
J Biol Chem
. 2006 Oct;
281(48):36985-92.
PMID: 17023430
Integrin-mediated adhesion is a crucial step in lymphocyte extravasation and homing. We show here that not only the chemokines CXCL12 and CXCL13 but also the lysophospholipids sphingosine 1-phosphate (S1P) and...
10.
Rieken S, Sassmann A, Herroeder S, Wallenwein B, Moers A, Offermanns S, et al.
J Immunol
. 2006 Aug;
177(5):2985-93.
PMID: 16920934
G protein-coupled receptors play an important role in the regulation of lymphocyte functions such as migration, adhesion, proliferation, and differentiation. Although the role of G(i) family G proteins has been...