Anthony Bouillon
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Explore the profile of Anthony Bouillon including associated specialties, affiliations and a list of published articles.
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11
Citations
344
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Recent Articles
1.
Puszko A, Batista F, Ejjoummany A, Bouillon A, Maurel M, Adler P, et al.
ChemMedChem
. 2025 Jan;
:e202400924.
PMID: 39832214
After more than 15 years of decline, the Malaria epidemy has increased again since 2017, reinforcing the need to identify drug candidates active on new targets involved in at least...
2.
Legru A, Batista F, Puszko A, Bouillon A, Maurel M, Martinez M, et al.
Eur J Med Chem
. 2024 Mar;
269:116308.
PMID: 38503166
Plasmodium multi-resistance, including against artemisinin, seriously threatens malaria treatment and control. Hence, new drugs are urgently needed, ideally targeting different parasitic stages, which are not yet targeted by current drugs....
3.
Martinez M, Bouillon A, Brule S, Raynal B, Haouz A, Alzari P, et al.
mBio
. 2024 Feb;
15(3):e0019824.
PMID: 38386597
Malaria symptoms are associated with the asexual multiplication of within human red blood cells (RBCs) and fever peaks coincide with the egress of daughter merozoites following the rupture of the...
4.
Martinez M, Batista F, Maurel M, Bouillon A, Ortega Varga L, Wehenkel A, et al.
Acta Crystallogr D Struct Biol
. 2023 Jul;
79(Pt 8):721-734.
PMID: 37428845
The constant selection and propagation of multi-resistant Plasmodium sp. parasites require the identification of new antimalarial candidates involved in as-yet untargeted metabolic pathways. Subtilisin-like protease 1 (SUB1) belongs to a...
5.
Mairet-Khedim M, Roesch C, Khim N, Srun S, Bouillon A, Kim S, et al.
J Antimicrob Chemother
. 2022 Dec;
78(2):411-417.
PMID: 36508338
Background: In early 2016, in Preah Vihear, Northern Cambodia, artesunate/mefloquine was used to cope with dihydroartemisinin/piperaquine-resistant Plasmodium falciparum parasites. Following this policy, P. falciparum strains harbouring molecular markers associated with...
6.
Witkowski B, Duru V, Khim N, Ross L, Saintpierre B, Beghain J, et al.
Lancet Infect Dis
. 2016 Nov;
17(2):174-183.
PMID: 27818097
Background: Western Cambodia is the epicentre of Plasmodium falciparum multidrug resistance and is facing high rates of dihydroartemisinin-piperaquine treatment failures. Genetic tools to detect the multidrug-resistant parasites are needed. Artemisinin...
7.
Bastianelli G, Bouillon A, Nguyen C, Le-Nguyen D, Nilges M, Barale J
PLoS One
. 2014 Oct;
9(10):e109269.
PMID: 25343504
Background: Malaria remains a major global health concern. The development of novel therapeutic strategies is critical to overcome the selection of multiresistant parasites. The subtilisin-like protease (SUB1) involved in the...
8.
Giganti D, Bouillon A, Tawk L, Robert F, Martinez M, Crublet E, et al.
Nat Commun
. 2014 Sep;
5:4833.
PMID: 25204226
The Plasmodium subtilase SUB1 plays a pivotal role during the egress of malaria parasites from host hepatocytes and erythrocytes. Here we report the crystal structure of full-length SUB1 from the...
9.
Bouillon A, Giganti D, Benedet C, Gorgette O, Petres S, Crublet E, et al.
J Biol Chem
. 2013 May;
288(25):18561-73.
PMID: 23653352
Widespread drug resistance calls for the urgent development of new antimalarials that target novel steps in the life cycle of Plasmodium falciparum and Plasmodium vivax. The essential subtilisin-like serine protease...
10.
Bouillon A, Gorgette O, Mercereau-Puijalon O, Barale J
Methods Mol Biol
. 2012 Sep;
923:523-34.
PMID: 22990802
Drug discovery programs heavily rely on assays adequately monitoring the activity of the drug on the -parasite stage targeted. So far, assays used to screen molecules active against Plasmodium falciparum...