Anna Philpott
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Explore the profile of Anna Philpott including associated specialties, affiliations and a list of published articles.
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79
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1910
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Recent Articles
1.
Azzarelli R, Gillen S, Connor F, Lundie-Brown J, Puletti F, Drummond R, et al.
Development
. 2024 Nov;
151(24).
PMID: 39575884
The proneural transcription factor ASCL1 regulates neurogenesis and drives somatic cell reprogramming into neurons. However, not all cell types can be reprogrammed by ASCL1, raising the questions of what provides...
2.
Ramachandran R, Ibragimova S, Woods L, AlHouqani T, Gomez R, Simeoni F, et al.
iScience
. 2024 Aug;
27(8):110500.
PMID: 39171293
Triple-negative breast cancer (TNBC) is characterized by lack of the estrogen (ER) receptor, progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2), and standard receptor-targeted therapies are ineffective. FOXC1,...
3.
Pereira A, Diwakar J, Masserdotti G, Beskardes S, Simon T, So Y, et al.
Nat Neurosci
. 2024 Jul;
27(7):1260-1273.
PMID: 38956165
Direct neuronal reprogramming is a promising approach to regenerate neurons from local glial cells. However, mechanisms of epigenome remodeling and co-factors facilitating this process are unclear. In this study, we...
4.
Ferguson K, Gillen S, Chaytor L, Poon E, Marcos D, Gomez R, et al.
Dev Cell
. 2023 Sep;
58(19):1967-1982.e8.
PMID: 37734383
Neuroblastoma is the most common extracranial solid tumor in infants, arising from developmentally stalled neural crest-derived cells. Driving tumor differentiation is a promising therapeutic approach for this devastating disease. Here,...
5.
Parkinson L, Gillen S, Woods L, Chaytor L, Marcos D, Ali F, et al.
Front Cell Dev Biol
. 2022 Oct;
10:942579.
PMID: 36263020
Neuroblastoma is believed to arise from sympathetic neuroblast precursors that fail to engage the neuronal differentiation programme, but instead become locked in a pro-proliferative developmental state. Achaete-scute homolog 1 (ASCL1)...
6.
Gomez R, Ibragimova S, Ramachandran R, Philpott A, Ali F
Biochim Biophys Acta Rev Cancer
. 2022 Sep;
1877(6):188805.
PMID: 36162542
Neuroblastoma is a solid, neuroendocrine tumor with divergent clinical behavior ranging from asymptomatic to fatal. The diverse clinical presentations of neuroblastoma are directly linked to the high intra- and inter-tumoral...
7.
Gomez R, Woods L, Ramachandran R, Abou Tayoun A, Philpott A, Ali F
Front Cell Dev Biol
. 2022 Sep;
10:943924.
PMID: 36147741
Neuroblastoma is a pediatric tumour that accounts for more than 15% of cancer-related deaths in children. High-risk tumours are often difficult to treat, and patients' survival chances are less than...
8.
Lee J, Kim S, Han S, Min J, Caldwell B, Bamford A, et al.
Cell Stem Cell
. 2022 May;
29(5):826-839.e9.
PMID: 35523142
Adult stem cells constantly react to local changes to ensure tissue homeostasis. In the main body of the stomach, chief cells produce digestive enzymes; however, upon injury, they undergo rapid...
9.
Elevated ASCL1 activity creates de novo regulatory elements associated with neuronal differentiation
Woods L, Ali F, Gomez R, Chernukhin I, Marcos D, Parkinson L, et al.
BMC Genomics
. 2022 Apr;
23(1):255.
PMID: 35366798
Background: The pro-neural transcription factor ASCL1 is a master regulator of neurogenesis and a key factor necessary for the reprogramming of permissive cell types to neurons. Endogenously, ASCL1 expression is...
10.
Azzarelli R, McNally A, DellAmico C, Onorati M, Simons B, Philpott A
Sci Rep
. 2022 Feb;
12(1):2341.
PMID: 35149717
The growth of glioblastoma (GBM), one of the deadliest adult cancers, is fuelled by a subpopulation of stem/progenitor cells, which are thought to be the source of resistance and relapse...