Fahad R Ali
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Explore the profile of Fahad R Ali including associated specialties, affiliations and a list of published articles.
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13
Citations
234
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Recent Articles
1.
Chekroun I, Shenbagam S, Almarri M, Mokrab Y, Uddin M, Alkhnbashi O, et al.
Nat Genet
. 2025 Feb;
57(3):505-514.
PMID: 39901015
The Greater Middle East (GME) represents a concentrated region of unparalleled genetic diversity, characterized by an abundance of distinct alleles, founder mutations and extensive autozygosity driven by high consanguinity rates....
2.
Ramachandran R, Ibragimova S, Woods L, AlHouqani T, Gomez R, Simeoni F, et al.
iScience
. 2024 Aug;
27(8):110500.
PMID: 39171293
Triple-negative breast cancer (TNBC) is characterized by lack of the estrogen (ER) receptor, progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2), and standard receptor-targeted therapies are ineffective. FOXC1,...
3.
Ferguson K, Gillen S, Chaytor L, Poon E, Marcos D, Gomez R, et al.
Dev Cell
. 2023 Sep;
58(19):1967-1982.e8.
PMID: 37734383
Neuroblastoma is the most common extracranial solid tumor in infants, arising from developmentally stalled neural crest-derived cells. Driving tumor differentiation is a promising therapeutic approach for this devastating disease. Here,...
4.
Parkinson L, Gillen S, Woods L, Chaytor L, Marcos D, Ali F, et al.
Front Cell Dev Biol
. 2022 Oct;
10:942579.
PMID: 36263020
Neuroblastoma is believed to arise from sympathetic neuroblast precursors that fail to engage the neuronal differentiation programme, but instead become locked in a pro-proliferative developmental state. Achaete-scute homolog 1 (ASCL1)...
5.
Gomez R, Ibragimova S, Ramachandran R, Philpott A, Ali F
Biochim Biophys Acta Rev Cancer
. 2022 Sep;
1877(6):188805.
PMID: 36162542
Neuroblastoma is a solid, neuroendocrine tumor with divergent clinical behavior ranging from asymptomatic to fatal. The diverse clinical presentations of neuroblastoma are directly linked to the high intra- and inter-tumoral...
6.
Gomez R, Woods L, Ramachandran R, Abou Tayoun A, Philpott A, Ali F
Front Cell Dev Biol
. 2022 Sep;
10:943924.
PMID: 36147741
Neuroblastoma is a pediatric tumour that accounts for more than 15% of cancer-related deaths in children. High-risk tumours are often difficult to treat, and patients' survival chances are less than...
7.
Elevated ASCL1 activity creates de novo regulatory elements associated with neuronal differentiation
Woods L, Ali F, Gomez R, Chernukhin I, Marcos D, Parkinson L, et al.
BMC Genomics
. 2022 Apr;
23(1):255.
PMID: 35366798
Background: The pro-neural transcription factor ASCL1 is a master regulator of neurogenesis and a key factor necessary for the reprogramming of permissive cell types to neurons. Endogenously, ASCL1 expression is...
8.
Ibragimova S, Ramachandran R, Ali F, Lipovich L, Ho S
Front Cell Dev Biol
. 2021 Dec;
9:725821.
PMID: 34869313
The recent increases in cancer incidences have been linked to lifestyle changes that result in obesity and metabolic syndrome. It is now evident that these trends are associated with the...
9.
Ali F, Marcos D, Chernukhin I, Woods L, Parkinson L, Wylie L, et al.
Mol Cancer Res
. 2020 Oct;
18(12):1759-1766.
PMID: 33046535
Pediatric cancers often resemble trapped developmental intermediate states that fail to engage the normal differentiation program, typified by high-risk neuroblastoma arising from the developing sympathetic nervous system. Neuroblastoma cells resemble...
10.
Hardwick L, Ali F, Azzarelli R, Philpott A
Cell Tissue Res
. 2014 May;
359(1):187-200.
PMID: 24859217
Formation of the central nervous system requires a period of extensive progenitor cell proliferation, accompanied or closely followed by differentiation; the balance between these two processes in various regions of...