Laura J A Hardwick
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Explore the profile of Laura J A Hardwick including associated specialties, affiliations and a list of published articles.
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19
Citations
220
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Recent Articles
1.
Hardwick L, Davies B, Pensa S, Burge-Rogers M, Davies C, Figueiredo Baptista A, et al.
J Mammary Gland Biol Neoplasia
. 2024 May;
29(1):10.
PMID: 38722417
Signal transducers and activators of transcription (STAT) proteins regulate mammary development. Here we investigate the expression of phosphorylated STAT3 (pSTAT3) in the mouse and cow around the day of birth....
2.
Hardwick L, Kortum A, Constantino-Casas F, Watson P
Vet Res Commun
. 2020 Dec;
45(1):21-30.
PMID: 33301127
Cellular senescence is a molecular hallmark of ageing that is associated with multiple pathologies, and DNA damage marker γH2AX, together with cell cycle inhibitor p21, have been used as senescence...
3.
Hardwick L, Phythian C, Fowden A, Hughes K
J Anat
. 2020 Jan;
236(5):954-962.
PMID: 31898326
Supernumerary nipples or teats (polythelia) are congenital accessory structures that may develop at any location along the milk line and have been implicated in the pathogenesis of mastitis. We describe...
4.
Hardwick L, Philpott A
Cold Spring Harb Protoc
. 2019 May;
2019(7).
PMID: 31138717
embryos have long been used to show phenotypic effects following overexpression of proteins of interest such as transcription factors. Posttranslational modification of these proteins can dramatically alter the extent of...
5.
Hardwick L, Philpott A
Cold Spring Harb Protoc
. 2019 May;
2019(7).
PMID: 31138716
embryos provide a rapid and accessible in vivo model, expressing a plethora of endogenous kinase and phosphatase enzymes that control protein phosphorylation and, in turn, affect physiological function. Traditionally, the...
6.
Hardwick L, Davies J, Philpott A
Biochem Biophys Res Commun
. 2019 Feb;
511(1):111-116.
PMID: 30773262
The superfamily of basic-Helix-Loop-Helix (bHLH) transcription factors influence cell fate in all three embryonic germ layers, and the tissue-specific class II factors have received prominent attention for their potent ability...
7.
Hardwick L, Philpott A
Biochem Biophys Res Commun
. 2019 Jan;
509(2):557-563.
PMID: 30600182
The processes of cell proliferation and differentiation are intimately linked during embryogenesis, and the superfamily of (basic) Helix-Loop-Helix (bHLH) transcription factors play critical roles in these events. For example, neuronal...
8.
Hardwick L, Philpott A
Front Physiol
. 2018 Dec;
9:1660.
PMID: 30538639
The use of the model system has provided diverse contributions to cancer research, not least because of the striking parallels between tumour pathogenesis and early embryo development. Cell cycle regulation,...
9.
Hardwick L, Philpott A
Wellcome Open Res
. 2018 Nov;
3:129.
PMID: 30430141
From the relatively simple nervous system of to the elaborate mammalian cortex, neurogenesis requires exceptional spatial and temporal precision to co-ordinate progenitor cell proliferation and subsequent differentiation to a diverse...
10.
Hardwick L, Philpott A
Wellcome Open Res
. 2018 Oct;
3:125.
PMID: 30363793
The proneural basic-helix-loop-helix (bHLH) transcription factor Ascl1 is a master regulator of neurogenesis in both central and peripheral nervous systems and is a central driver of neuronal reprogramming . Over...