Ankit Seth
Overview
Explore the profile of Ankit Seth including associated specialties, affiliations and a list of published articles.
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22
Citations
273
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Recent Articles
1.
Seth A, Mathur A
J Midlife Health
. 2021 Sep;
12(2):179-184.
PMID: 34526755
We report two rare cases of genital angioleiomyomas (ALs), one each of uterus and cervix. The uterine AL showed a very rare presentation of endometrial polyp, while the cervical AL...
2.
Choubey P, Tripathi A, Tripathi M, Seth A, Shrivastava S
Bioorg Chem
. 2021 May;
111:104922.
PMID: 33945941
Novel N-Benzylpyrrolidine hybrids were designed, synthesized, and tested against multiple in-vitro and in-vivo parameters. Among all the synthesized molecules, 8f and 12f showed extensive inhibition against beta-secretase-1 (hBACE-1), human acetylcholinesterase...
3.
Tripathi M, Sharma P, Tripathi A, Tripathi P, Srivastava P, Seth A, et al.
J Comput Aided Mol Des
. 2020 Jun;
34(9):983-1002.
PMID: 32488355
The cholinesterases are essential targets implicated in the pathogenesis of Alzheimer's disease (AD). In the present study, virtual screening and molecular docking are performed to identify the potential hits. Docking-post...
4.
Tripathi A, Choubey P, Sharma P, Seth A, Saraf P, Shrivastava S
Bioorg Chem
. 2019 Dec;
95:103506.
PMID: 31887472
Thirty ferulic acid-based 1,3,4-oxadiazole molecular hybrids were designed, synthesized, and screened them for multifunctional inhibitory potential against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and beta-secretase-1 (BACE-1). Compound 6j was the most potent...
5.
Tripathi A, Choubey P, Sharma P, Seth A, Tripathi P, Tripathi M, et al.
Eur J Med Chem
. 2019 Sep;
183:111707.
PMID: 31561043
The diverse nature of Alzheimer's disease (AD) has prompted researchers to develop multi-functional agents. Herein, we have designed and synthesized molecular hybrids of 2-pyridylpiperazine and 5-phenyl-1,3,4-oxadiazoles. Biological activities of synthesized...
6.
Mishra P, Sharma P, Tripathi P, Gupta S, Srivastava P, Seth A, et al.
Bioorg Chem
. 2019 Jun;
89:103025.
PMID: 31176239
The novel hybrids bearing 4-aminopyridine (4-AP) tethered with substituted 1,3,4-oxadiazole nucleus were designed, synthesized, and evaluated for their potential AChE inhibitory property along with significant antioxidant potential. The inhibitory potential...
7.
Tripathi P, Srivastava P, Sharma P, Seth A, Shrivastava S
Bioorg Med Chem
. 2019 Feb;
27(7):1327-1340.
PMID: 30795991
Novel hybrids bearing a 2-aminopyrimidine (2-AP) moiety linked to substituted 1,3,4-oxadiazoles were designed, synthesized and biologically evaluated. Among the developed compounds, 28 noncompetitively inhibited human acetylcholinesterase (hAChE; pIC = 6.52;...
8.
Sharma P, Tripathi A, Tripathi P, Prajapati S, Seth A, Tripathi M, et al.
Eur J Med Chem
. 2019 Feb;
167:510-524.
PMID: 30784883
The multitarget-directed strategy offers an effective and promising paradigm to treat the complex neurodegenerative disorder, such as Alzheimer's disease (AD). Herein, a series of N-benzylpiperidine analogs (17-31 and 32-46) were...
9.
Tripathi P, Srivastava P, Sharma P, Tripathi M, Seth A, Tripathi A, et al.
Bioorg Chem
. 2019 Jan;
85:82-96.
PMID: 30605887
A series of novel piperazine tethered biphenyl-3-oxo-1,2,4-triazine derivatives were designed, and synthesized. Amongst the synthesized analogs, compound 6g showed significant non-competitive inhibitory potential against acetylcholinesterase (AChE, IC; 0.2 ± 0.01 ...
10.
Sharma P, Srivastava P, Seth A, Tripathi P, Banerjee A, Shrivastava S
Prog Neurobiol
. 2019 Jan;
174:53-89.
PMID: 30599179
AD is a progressive neurodegenerative disorder and a leading cause of dementia in an aging population worldwide. The enormous challenge which AD possesses to global healthcare makes it as urgent...