Andrew Wakeham
Overview
Explore the profile of Andrew Wakeham including associated specialties, affiliations and a list of published articles.
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Articles
73
Citations
5926
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0
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Recent Articles
1.
Kawazu M, Saso K, Tong K, McQuire T, Goto K, Son D, et al.
PLoS One
. 2024 May;
19(5):e0303780.
PMID: 38722939
[This corrects the article DOI: 10.1371/journal.pone.0017830.].
2.
Suarez J, Novelli F, Goto K, Ehara M, Steele M, Kim J, et al.
Proc Natl Acad Sci U S A
. 2023 Sep;
120(39):e2307999120.
PMID: 37729199
Asbestos is the main cause of malignant mesothelioma. Previous studies have linked asbestos-induced mesothelioma to the release of HMGB1 from the nucleus to the cytoplasm, and from the cytoplasm to...
3.
Yu H, Worrall L, Berger T, Petric M, Lin B, Vuckovic M, et al.
J Immunol
. 2023 Jul;
211(6):981-993.
PMID: 37493438
Current vaccine efforts to combat SARS-CoV-2 are focused on the whole spike protein administered as mRNA, viral vector, or protein subunit. However, the SARS-CoV-2 receptor-binding domain (RBD) is the immunodominant...
4.
Lukhele S, Rabbo D, Guo M, Shen J, Elsaesser H, Quevedo R, et al.
Immunity
. 2022 Nov;
55(12):2369-2385.e10.
PMID: 36370712
Type I and II interferons (IFNs) stimulate pro-inflammatory programs that are critical for immune activation, but also induce immune-suppressive feedback circuits that impede control of cancer growth. Here, we sought...
5.
Bassi C, Fortin J, Snow B, Wakeham A, Ho J, Haight J, et al.
Cell Death Differ
. 2021 Jun;
28(11):3036-3051.
PMID: 34059798
The tumor suppressor PTEN is disrupted in a large proportion of cancers, including in HER2-positive breast cancer, where its loss is associated with resistance to therapy. Upon genotoxic stress, ataxia...
6.
Martin O, Bergonzini A, Chiloeches M, Paparouna E, Butter D, Theodorou S, et al.
Cell Rep
. 2021 Apr;
35(1):108931.
PMID: 33826883
Bacterial genotoxins cause DNA damage in eukaryotic cells, resulting in activation of the DNA damage response (DDR) in vitro. These toxins are produced by Gram-negative bacteria, enriched in the microbiota...
7.
Fortin J, Bassi C, Ramachandran P, Li W, Tian R, Zarrabi I, et al.
J Clin Invest
. 2021 Jan;
131(5).
PMID: 33444287
In order to sustain proficient life-long hematopoiesis, hematopoietic stem cells (HSCs) must possess robust mechanisms to preserve their quiescence and genome integrity. DNA-damaging stress can perturb HSC homeostasis by affecting...
8.
Gu Y, Yang R, Yang Y, Zhao Y, Wakeham A, Li W, et al.
Blood
. 2020 Nov;
137(7):945-958.
PMID: 33254233
Isocitrate dehydrogenase (IDH) mutations are common genetic alterations in myeloid disorders, including acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). Epigenetic changes, including abnormal histone and DNA methylation, have been...
9.
Fortin J, Tian R, Zarrabi I, Hill G, Williams E, Sanchez-Duffhues G, et al.
Cancer Cell
. 2020 Mar;
37(3):308-323.e12.
PMID: 32142668
Diffuse intrinsic pontine gliomas (DIPGs) are aggressive pediatric brain tumors for which there is currently no effective treatment. Some of these tumors combine gain-of-function mutations in ACVR1, PIK3CA, and histone...
10.
Kubli S, Vornholz L, Duncan G, Zhou W, Ramachandran P, Fortin J, et al.
Nat Commun
. 2019 Sep;
10(1):4069.
PMID: 31481706
An amendment to this paper has been published and can be accessed via a link at the top of the paper.