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Andrew W Foster

Explore the profile of Andrew W Foster including associated specialties, affiliations and a list of published articles. Areas
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Articles 19
Citations 559
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Recent Articles
1.
Young T, Deery E, Foster A, Martini M, Osman D, Warren M, et al.
JACS Au . 2023 May; 3(5):1472-1483. PMID: 37234125
The acquisition of Co by the corrin component of vitamin B follows one of two distinct pathways, referred to as early or late Co insertion. The late insertion pathway exploits...
2.
Foster A, Clough S, Aki Z, Young T, Clarke A, Robinson N
Metallomics . 2022 Aug; 14(9). PMID: 35933161
Three Web-based calculators, and three analogous spreadsheets, have been generated that predict in vivo metal occupancies of proteins based on known metal affinities. The calculations exploit estimates of the availabilities...
3.
Foster A, Young T, Chivers P, Robinson N
Curr Opin Chem Biol . 2021 Nov; 66:102095. PMID: 34763208
Inorganic metals supplement the chemical repertoire of organic molecules, especially proteins. This requires the correct metals to associate with proteins at metalation. Protein mismetalation typically occurs when excesses of unbound...
4.
Young T, Martini M, Foster A, Glasfeld A, Osman D, Morton R, et al.
Nat Commun . 2021 Feb; 12(1):1195. PMID: 33608553
Protein metal-occupancy (metalation) in vivo has been elusive. To address this challenge, the available free energies of metals have recently been determined from the responses of metal sensors. Here, we...
5.
Osman D, Martini M, Foster A, Chen J, Scott A, Morton R, et al.
Nat Chem Biol . 2019 Jan; 15(3):241-249. PMID: 30692683
There is a challenge for metalloenzymes to acquire their correct metals because some inorganic elements form more stable complexes with proteins than do others. These preferences can be overcome provided...
6.
Osman D, Foster A, Chen J, Svedaite K, Steed J, Lurie-Luke E, et al.
Nat Commun . 2017 Dec; 8(1):1884. PMID: 29192165
Bacteria possess transcription factors whose DNA-binding activity is altered upon binding to specific metals, but metal binding is not specific in vitro. Here we show that tight regulation of buffered...
7.
Carr C, Foster A, Maroney M
J Inorg Biochem . 2017 Aug; 177:352-358. PMID: 28844329
InrS (Internal nickel-responsive Sensor) is a transcriptional repressor of the nickel exporter NrsD and de-represses expression of the exporter upon binding Ni(II) ions. Although a crystal structure of apo-InrS has...
8.
Foster A, Pernil R, Patterson C, Scott A, Palsson L, Pal R, et al.
Nat Chem Biol . 2017 Feb; 13(4):409-414. PMID: 28166209
The metal affinities of metal-sensing transcriptional regulators co-vary with cellular metal concentrations over more than 12 orders of magnitude. To understand the cause of this relationship, we determined the structure...
9.
Rubio M, Napolitano M, Ochoa de Alda J, Santamaria-Gomez J, Patterson C, Foster A, et al.
Nucleic Acids Res . 2015 Oct; 43(20):9905-17. PMID: 26464444
Aminoacyl-tRNA synthetases (aaRSs) play a key role in deciphering the genetic message by producing charged tRNAs and are equipped with proofreading mechanisms to ensure correct pairing of tRNAs with their...
10.
Osman D, Piergentili C, Chen J, Chakrabarti B, Foster A, Lurie-Luke E, et al.
J Biol Chem . 2015 Jun; 290(32):19806-22. PMID: 26109070
FrmR from Salmonella enterica serovar typhimurium (a CsoR/RcnR-like transcriptional de-repressor) is shown to repress the frmRA operator-promoter, and repression is alleviated by formaldehyde but not manganese, iron, cobalt, nickel, copper,...