Nigel J Robinson
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Explore the profile of Nigel J Robinson including associated specialties, affiliations and a list of published articles.
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56
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2583
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Recent Articles
1.
Clough S, Young T, Tarrant E, Scott A, Chivers P, Glasfeld A, et al.
Nat Commun
. 2025 Jan;
16(1):810.
PMID: 39827241
It has been challenging to test how proteins acquire specific metals in cells. The speciation of metalation is thought to depend on the preferences of proteins for different metals competing...
2.
Young T, Deery E, Foster A, Martini M, Osman D, Warren M, et al.
JACS Au
. 2023 May;
3(5):1472-1483.
PMID: 37234125
The acquisition of Co by the corrin component of vitamin B follows one of two distinct pathways, referred to as early or late Co insertion. The late insertion pathway exploits...
3.
Osman D, Robinson N
FEBS Lett
. 2022 Sep;
597(1):141-150.
PMID: 36124565
Metalation, the acquisition of metals by proteins, must avoid mis-metalation with tighter binding metals. This is illustrated by four selected proteins that require different metals: all show similar ranked orders...
4.
Foster A, Clough S, Aki Z, Young T, Clarke A, Robinson N
Metallomics
. 2022 Aug;
14(9).
PMID: 35933161
Three Web-based calculators, and three analogous spreadsheets, have been generated that predict in vivo metal occupancies of proteins based on known metal affinities. The calculations exploit estimates of the availabilities...
5.
Foster A, Young T, Chivers P, Robinson N
Curr Opin Chem Biol
. 2021 Nov;
66:102095.
PMID: 34763208
Inorganic metals supplement the chemical repertoire of organic molecules, especially proteins. This requires the correct metals to associate with proteins at metalation. Protein mismetalation typically occurs when excesses of unbound...
6.
Young T, Martini M, Foster A, Glasfeld A, Osman D, Morton R, et al.
Nat Commun
. 2021 Feb;
12(1):1195.
PMID: 33608553
Protein metal-occupancy (metalation) in vivo has been elusive. To address this challenge, the available free energies of metals have recently been determined from the responses of metal sensors. Here, we...
7.
Osman D, Cooke A, Young T, Deery E, Robinson N, Warren M
Biochim Biophys Acta Mol Cell Res
. 2020 Oct;
1868(1):118896.
PMID: 33096143
Vitamin B, cobalamin, is a cobalt-containing ring-contracted modified tetrapyrrole that represents one of the most complex small molecules made by nature. In prokaryotes it is utilised as a cofactor, coenzyme,...
8.
Robinson N, Glasfeld A
J Biol Inorg Chem
. 2020 Apr;
25(4):543-545.
PMID: 32333210
The association of proteins with metals, metalation, is challenging because the tightest binding metals are rarely the correct ones. Inside cells, correct metalation is enabled by controlled bioavailability plus extra...
9.
Osman D, Martini M, Foster A, Chen J, Scott A, Morton R, et al.
Nat Chem Biol
. 2019 Jan;
15(3):241-249.
PMID: 30692683
There is a challenge for metalloenzymes to acquire their correct metals because some inorganic elements form more stable complexes with proteins than do others. These preferences can be overcome provided...
10.
Osman D, Foster A, Chen J, Svedaite K, Steed J, Lurie-Luke E, et al.
Nat Commun
. 2017 Dec;
8(1):1884.
PMID: 29192165
Bacteria possess transcription factors whose DNA-binding activity is altered upon binding to specific metals, but metal binding is not specific in vitro. Here we show that tight regulation of buffered...