Rafael Pernil
Overview
Explore the profile of Rafael Pernil including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
315
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Recent Articles
1.
Graf J, Fresenborg L, Seitz H, Pernil R, Schleiff E
Microb Cell
. 2024 Feb;
11:41-56.
PMID: 38379927
Metal homeostasis is central to all forms of life, as metals are essential micronutrients with toxic effects at elevated levels. Macromolecular machines facilitate metal uptake into the cells and their...
2.
Graf J, Schopperle M, Pernil R, Schleiff E
Microb Cell
. 2024 Jan;
11:16-28.
PMID: 38234586
Low availability of micronutrients such as iron has enforced the evolution of uptake systems in all kingdoms of life. In Gram-negative bacteria, outer membrane, periplasmatic and plasma membrane localized proteins...
3.
Pernil R, Schleiff E
Life (Basel)
. 2019 Apr;
9(2).
PMID: 30987221
Cyanobacteria are photoautotrophic microorganisms present in almost all ecologically niches on Earth. They exist as single-cell or filamentous forms and the latter often contain specialized cells for N₂ fixation known...
4.
Foster A, Pernil R, Patterson C, Scott A, Palsson L, Pal R, et al.
Nat Chem Biol
. 2017 Feb;
13(4):409-414.
PMID: 28166209
The metal affinities of metal-sensing transcriptional regulators co-vary with cellular metal concentrations over more than 12 orders of magnitude. To understand the cause of this relationship, we determined the structure...
5.
Rudolf M, Stevanovic M, Kranzler C, Pernil R, Keren N, Schleiff E
Plant Mol Biol
. 2016 Jun;
92(1-2):57-69.
PMID: 27325117
Many cyanobacteria secrete siderophores to sequester iron. Alternatively, mechanisms to utilize xenosiderophores have evolved. The overall uptake systems are comparable to that of other bacteria involving outer membrane transporters energized...
6.
Rudolf M, Tetik N, Ramos-Leon F, Flinner N, Ngo G, Stevanovic M, et al.
mBio
. 2015 Jul;
6(4):e00376.
PMID: 26126850
Unlabelled: Filamentous, heterocyst-forming cyanobacteria exchange nutrients and regulators between cells for diazotrophic growth. Two alternative modes of exchange have been discussed involving transport either through the periplasm or through septal...
7.
Pernil R, Picossi S, Herrero A, Flores E, Mariscal V
Life (Basel)
. 2015 Apr;
5(2):1282-300.
PMID: 25915115
Anabaena sp. strain PCC 7120 is a filamentous cyanobacterium that can use inorganic compounds such as nitrate or ammonium as nitrogen sources. In the absence of combined nitrogen, it can...
8.
Foster A, Pernil R, Patterson C, Robinson N
Mol Microbiol
. 2014 Mar;
92(4):797-812.
PMID: 24666373
InrS is a Ni(II)-responsive, CsoR/RcnR-like, DNA-binding transcriptional repressor of the nrsD gene, but the Ni(II) co-ordination sphere of InrS is unlike Ni(II)-RcnR. We show that copper and Zn(II) also bind...
9.
Patterson C, Pernil R, Dainty S, Chakrabarti B, Henry C, Money V, et al.
Metallomics
. 2013 Feb;
5(4):352-62.
PMID: 23420021
The MerR-like transcriptional activator CoaR detects surplus Co(ll) to regulate Co(ll) efflux in a cyanobacterium. This organism also has cytosolic metal-sensors from three further families represented by Zn(ll)-sensors ZiaR and...
10.
Foster A, Patterson C, Pernil R, Hess C, Robinson N
J Biol Chem
. 2012 Feb;
287(15):12142-51.
PMID: 22356910
Efflux of surplus Ni(II) across the outer and inner membranes of Synechocystis PCC 6803 is mediated by the Nrs system under the control of a sensor of periplasmic Ni(II), NrsS....