Protein Metalation in Biology

Overview

Journal Curr Opin Chem Biol

Publisher Elsevier

Specialty Biochemistry

Date 2021 Nov 11

PMID 34763208

Citations 38

Authors

Andrew W Foster

Tessa R Young

Peter T Chivers

Nigel J Robinson

Affiliations

Soon will be listed here.

Abstract

Inorganic metals supplement the chemical repertoire of organic molecules, especially proteins. This requires the correct metals to associate with proteins at metalation. Protein mismetalation typically occurs when excesses of unbound metals compete for a binding site ex vivo. However, in biology, excesses of metal-binding sites typically compete for limiting amounts of exchangeable metals. Here, we summarise mechanisms of metal homeostasis that sustain optimal metal availabilities in biology. We describe recent progress to understand metalation by comparing the strength of metal binding to a protein versus the strength of binding to competing sites inside cells.

Citing Articles

Metals in Motion: Understanding Labile Metal Pools in Bacteria.

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PMID: 39755956 PMC: 11755726. DOI: 10.1021/acs.biochem.4c00726.

Bacterial Metallostasis: Metal Sensing, Metalloproteome Remodeling, and Metal Trafficking.

Capdevila D, Rondon J, Edmonds K, Rocchio J, Villarruel Dujovne M, Giedroc D Chem Rev. 2024; 124(24):13574-13659.

PMID: 39658019 PMC: 11672702. DOI: 10.1021/acs.chemrev.4c00264.

Physiological cost of antibiotic resistance: Insights from a ribosome variant in bacteria.

Moon E, Modi T, Lee D, Yangaliev D, Garcia-Ojalvo J, Ozkan S Sci Adv. 2024; 10(46):eadq5249.

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Study of excess manganese stress response highlights the central role of manganese exporter Mnx for holding manganese homeostasis in the cyanobacterium sp. PCC 6803.

Reis M, Zenker S, Viehover P, Niehaus K, Brautigam A, Eisenhut M Microbiology (Reading). 2024; 170(11).

PMID: 39508727 PMC: 11649195. DOI: 10.1099/mic.0.001515.

Impact of Metal Ions on Cellular Functions: A Focus on Mesenchymal Stem/Stromal Cell Differentiation.

Peters K, Staehlke S, Rebl H, Jonitz-Heincke A, Hahn O Int J Mol Sci. 2024; 25(18).

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