Andrew Sandstrom
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Explore the profile of Andrew Sandstrom including associated specialties, affiliations and a list of published articles.
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12
Citations
1015
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Recent Articles
1.
Sandstrom A
J Exp Med
. 2022 Nov;
220(1).
PMID: 36374226
In this issue of JEM, Jenster et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20220837) investigate how UVB radiation promotes activation of the inflammatory immune sensor NLRP1, and in doing so uncover...
2.
Daskalov A, Mitchell P, Sandstrom A, Vance R, Glass N
Proc Natl Acad Sci U S A
. 2020 Jul;
117(31):18600-18607.
PMID: 32703806
Programmed cell death (PCD) in filamentous fungi prevents cytoplasmic mixing following fusion between conspecific genetically distinct individuals (allorecognition) and serves as a defense mechanism against mycoparasitism, genome exploitation, and deleterious...
3.
Mitchell P, Sandstrom A, Vance R
Curr Opin Immunol
. 2019 May;
60:37-45.
PMID: 31121538
Nucleotide-binding domain, leucine-rich repeat (NLR) proteins constitute a diverse class of innate immune sensors that detect pathogens or stress-associated stimuli in plants and animals. Some NLRs are activated upon direct...
4.
Sandstrom A, Mitchell P, Goers L, Mu E, Lesser C, Vance R
Science
. 2019 Mar;
364(6435).
PMID: 30872533
Inflammasomes are multiprotein platforms that initiate innate immunity by recruitment and activation of caspase-1. The NLRP1B inflammasome is activated upon direct cleavage by the anthrax lethal toxin protease. However, the...
5.
Sandstrom A, Vance R
J Exp Med
. 2018 Feb;
215(3):723-724.
PMID: 29440361
In this issue of JEM, Boucher et al. (https://doi.org/10.1084/jem.20172222) report isolation of active caspase-1 from macrophages after inflammasome activation. Surprisingly, they find that caspase-1 is quickly inactivated upon autoproteolytic processing.
6.
Dopfer E, Hartl F, Oberg H, Siegers G, Yousefi O, Kock S, et al.
Cell Rep
. 2014 May;
7(5):1704-1715.
PMID: 24857663
Activation of the T cell receptor (TCR) by antigen is the key step in adaptive immunity. In the αβTCR, antigen induces a conformational change at the CD3 subunits (CD3 CC)...
7.
Sandstrom A, Peigne C, Leger A, Crooks J, Konczak F, Gesnel M, et al.
Immunity
. 2014 Apr;
40(4):490-500.
PMID: 24703779
In humans, Vγ9Vδ2 T cells detect tumor cells and microbial infections, including Mycobacterium tuberculosis, through recognition of small pyrophosphate containing organic molecules known as phosphoantigens (pAgs). Key to pAg-mediated activation...
8.
Palakodeti A, Sandstrom A, Sundaresan L, Harly C, Nedellec S, Olive D, et al.
J Biol Chem
. 2012 Aug;
287(39):32780-90.
PMID: 22846996
Human Vγ9Vδ2 T cells are well known for their rapid and potent response to infection and tumorigenesis when in the presence of endogenous or exogenous phosphoisoprenoids. However, the molecular mechanisms...
9.
Sandstrom A, Scharf L, McRae G, Hawk A, Meredith S, Adams E
J Biol Chem
. 2012 Jan;
287(8):6035-43.
PMID: 22215668
The molecular mechanisms by which γδ T cells recognize ligand remain a mystery. The non-classical MHC molecule T22 represents the best characterized ligand for murine γδ T cells, with a...
10.
Rizk S, Paduch M, Heithaus J, Duguid E, Sandstrom A, Kossiakoff A
Nat Struct Mol Biol
. 2011 Mar;
18(4):437-42.
PMID: 21378967
We describe a phage display methodology for engineering synthetic antigen binders (sABs) that recognize either the apo or the ligand-bound conformation of maltose-binding protein (MBP). sABs that preferentially recognize the...