Balbino Alarcon
Overview
Explore the profile of Balbino Alarcon including associated specialties, affiliations and a list of published articles.
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95
Citations
2464
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Recent Articles
1.
Hortal A, Calleja E, Oeste C, Arellano I, Lacuna M, Blanco S, et al.
Sci Signal
. 2025 Jan;
18(871):eadk4204.
PMID: 39874377
The small GTPase R-RAS2 regulates homeostatic proliferation and survival of T and B lymphocytes and, when present in high amounts, drives the development of B cell chronic lymphocytic leukemia. In...
2.
Alarcon B, Schamel W
Immunol Rev
. 2025 Jan;
329(1):e13438.
PMID: 39754405
Rather than being contained in a single polypeptide, and unlike receptor tyrosine kinases, the T cell receptor (TCR) divides its signaling functions among its subunits: TCRα/β bind the extracellular ligand,...
3.
Cifuentes C, Oeste C, Fernandez-Pisonero I, Hortal A, Garcia-Macias C, Hochart J, et al.
Mol Cancer
. 2024 Jul;
23(1):142.
PMID: 38987766
Background: Breast cancer (BC) is the most common cancer in women, with triple negative BC (TNBC) accounting for 20% of cases. While early detection and targeted therapies have improved overall...
4.
Hortal A, Villanueva A, Arellano I, Prieto C, Mendoza P, Bustelo X, et al.
Cancers (Basel)
. 2023 Dec;
15(24).
PMID: 38136362
B-cell chronic lymphocytic leukemia (B-CLL) is the most common type of leukemia in the Western world. Mutation in different genes, such as and , and deletions at specific chromosomic regions,...
5.
Lacuna M, Hortal A, Cifuentes C, Gonzalo T, Alcoceba M, Bastos M, et al.
Cells
. 2023 Dec;
12(23).
PMID: 38067115
Chronic lymphocytic leukemia (CLL) is a hematologic malignancy characterized by progressive accumulation of a rare population of CD5+ B-lymphocytes in peripheral blood, bone marrow, and lymphoid tissues. CLL exhibits remarkable...
6.
Martinez-Martin N, Alarcon B
Biomed J
. 2023 Jul;
47(5):100630.
PMID: 37459965
Trogocytosis is an active process whereby fragments of plasma membrane proteins and cytoplasm are transferred from one cell to another in a cell-cell contact-dependent manner. T cells trogocytose pieces of...
7.
Horndler L, Delgado P, Romero-Pinedo S, Quesada M, Balabanov I, Laguna-Goya R, et al.
Front Immunol
. 2023 Apr;
14:1157263.
PMID: 37081876
Introduction: The rapid development of vaccines to prevent COVID-19 has raised the need to compare the capacity of different vaccines in terms of developing a protective humoral response. Previous studies...
8.
Martinez-Riano A, Delgado P, Tercero R, Barrero S, Mendoza P, Oeste C, et al.
Commun Biol
. 2023 Apr;
6(1):437.
PMID: 37081131
Successful vaccines rely on activating a functional humoral immune response through the generation of class-switched high affinity immunoglobulins (Igs). The germinal center (GC) reaction is crucial for this process, in...
9.
Hortal A, Lacuna M, Cifuentes C, Alcoceba M, Bustelo X, Gonzalez M, et al.
Cancers (Basel)
. 2023 Feb;
15(3).
PMID: 36765602
Unlike classical genes, oncogenic mutations on are seldomly found in human cancer. By contrast, is frequently found overexpressed in a number of human tumors, including B and T cell lymphomas,...
10.
Clavain L, Fernandez-Pisonero I, Movilla N, Lorenzo-Martin L, Nieto B, Abad A, et al.
Oncogene
. 2022 Dec;
42(5):389-405.
PMID: 36476833
The R-RAS2 GTP hydrolase (GTPase) (also known as TC21) has been traditionally considered quite similar to classical RAS proteins at the regulatory and signaling levels. Recently, a long-tail hotspot mutation...