Andrew S Weyrich
Overview
Explore the profile of Andrew S Weyrich including associated specialties, affiliations and a list of published articles.
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127
Citations
6820
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Recent Articles
11.
Bhatlekar S, Manne B, Basak I, Edelstein L, Tugolukova E, Stoller M, et al.
Blood
. 2020 Aug;
136(15):1760-1772.
PMID: 32844999
There is heritability to interindividual variation in platelet count, and better understanding of the regulating genetic factors may provide insights for thrombopoiesis. MicroRNAs (miRs) regulate gene expression in health and...
12.
de Azevedo-Quintanilha I, Medeiros-de-Moraes I, Ferreira A, Reis P, Vieira-de-Abreu A, Campbell R, et al.
Malar J
. 2020 Jul;
19(1):234.
PMID: 32611348
Background: Malaria-triggered lung injury can occur in both severe and non-severe cases. Platelets may interact with parasitized erythrocytes, leukocytes and endothelium. These interactions can lead to microvessel obstructions and induce...
13.
Middleton E, He X, Denorme F, Campbell R, Ng D, Salvatore S, et al.
Blood
. 2020 Jun;
136(10):1169-1179.
PMID: 32597954
COVID-19 affects millions of patients worldwide, with clinical presentation ranging from isolated thrombosis to acute respiratory distress syndrome (ARDS) requiring ventilator support. Neutrophil extracellular traps (NETs) originate from decondensed chromatin...
14.
Manne B, Denorme F, Middleton E, Portier I, Rowley J, Stubben C, et al.
Blood
. 2020 Jun;
136(11):1317-1329.
PMID: 32573711
There is an urgent need to understand the pathogenesis of coronavirus disease 2019 (COVID-19). In particular, thrombotic complications in patients with COVID-19 are common and contribute to organ failure and...
15.
Manne B, Bhatlekar S, Middleton E, Weyrich A, Borst O, Rondina M
J Thromb Haemost
. 2020 Jan;
18(5):1183-1196.
PMID: 31997536
Background: Regulated protein synthesis is essential for megakaryocyte (MK) and platelet functions, including platelet production and activation. PDK1 (phosphoinositide-dependent kinase 1) regulates platelet functional responses and has been associated with...
16.
de Azevedo-Quintanilha I, Vieira-de-Abreu A, Ferreira A, Reis P, Silva T, Nascimento D, et al.
PLoS One
. 2019 Dec;
14(12):e0224610.
PMID: 31869339
Malaria is an infectious disease of major worldwide clinical importance that causes a variety of severe, or complicated, syndromes including cerebral malaria, which is often fatal. Leukocyte integrins are essential...
17.
Rondina M, Voora D, Simon L, Schwertz H, Harper J, Lee O, et al.
Circ Res
. 2019 Dec;
126(4):501-516.
PMID: 31852401
Rationale: Longitudinal studies are required to distinguish within versus between-individual variation and repeatability of gene expression. They are uniquely positioned to decipher genetic signal from environmental noise, with potential application...
18.
Middleton E, Rowley J, Campbell R, Grissom C, Brown S, Beesley S, et al.
Blood
. 2019 Aug;
134(12):911-923.
PMID: 31366617
There is increasing recognition that platelets have a functional role in the pathophysiology of sepsis, though this role has not been precisely defined. Whether sepsis alters the human platelet transcriptome...
19.
Fidler T, Marti A, Gerth K, Middleton E, Campbell R, Rondina M, et al.
Diabetes
. 2019 Feb;
68(5):932-938.
PMID: 30765335
Patients with type 1 diabetes mellitus (T1DM) have increased thrombosis and platelet activation. The mechanisms for platelet hyperactivation in diabetes are incompletely understood. T1DM is accompanied by hyperglycemia, dyslipidemia, and...
20.
Bhatlekar S, Basak I, Edelstein L, Campbell R, Lindsey C, Italiano Jr J, et al.
Haematologica
. 2019 Feb;
104(10):2075-2083.
PMID: 30733267
Apoptosis is a recognized limitation to generating large numbers of megakaryocytes in culture. The genes responsible have been rigorously studied in mice, but are poorly characterized in human culture systems....