Andrew R Gorringe
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Explore the profile of Andrew R Gorringe including associated specialties, affiliations and a list of published articles.
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28
Citations
645
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Recent Articles
1.
Dale A, Theodosiou A, Gbesemete D, Guy J, Jones E, Hill A, et al.
Lancet Microbe
. 2022 Dec;
3(12):e931-e943.
PMID: 36462524
Background: Pharyngeal colonisation by the commensal bacterium Neisseria lactamica inhibits colonisation by Neisseria meningitidis and has an inverse epidemiological association with meningococcal disease. The mechanisms that underpin this relationship are...
2.
Abrahams J, Weigand M, Ring N, MacArthur I, Etty J, Peng S, et al.
Microb Genom
. 2022 Feb;
8(2).
PMID: 35143385
Bacterial genetic diversity is often described solely using base-pair changes despite a wide variety of other mutation types likely being major contributors. Tandem duplication/amplifications are thought to be widespread among...
3.
Laver J, Gbesemete D, Dale A, Pounce Z, Webb C, Roche E, et al.
Sci Transl Med
. 2021 Jul;
13(601).
PMID: 34233953
The human nasopharynx contains a stable microbial ecosystem of commensal and potentially pathogenic bacteria, which can elicit protective primary and secondary immune responses. Experimental intranasal infection of human adults with...
4.
Holubova J, Stanek O, Brazdilova L, Masin J, Bumba L, Gorringe A, et al.
Vaccines (Basel)
. 2020 Nov;
8(4).
PMID: 33228165
whole-cell vaccines (wP) caused a spectacular drop of global pertussis incidence, but since the replacement of wP with acellular pertussis vaccines (aP), pertussis has resurged in developed countries within 7...
5.
de Graaf H, Gbesemete D, Gorringe A, Diavatopoulos D, Kester K, Faust S, et al.
BMJ Open
. 2017 Oct;
7(10):e018594.
PMID: 29025851
Introduction: We summarise an ethically approved protocol for the development of an experimental human challenge colonisation model. Globally is one of the leading causes of vaccine-preventable death. Many countries have...
6.
Linz B, Ivanov Y, Preston A, Brinkac L, Parkhill J, Kim M, et al.
BMC Genomics
. 2016 Oct;
17(1):767.
PMID: 27716057
Background: The genus Bordetella consists of nine species that include important respiratory pathogens such as the 'classical' species B. bronchiseptica, B. pertussis and B. parapertussis and six more distantly related...
7.
Pratt A, DiDonato M, Shin D, Cabelli D, Bruns C, Belzer C, et al.
J Bacteriol
. 2015 Oct;
197(24):3834-47.
PMID: 26459556
Unlabelled: Bacterial pathogens Neisseria meningitidis and Brucella abortus pose threats to human and animal health worldwide, causing meningococcal disease and brucellosis, respectively. Mortality from acute N. meningitidis infections remains high...
8.
Deasy A, Guccione E, Dale A, Andrews N, Evans C, Bennett J, et al.
Clin Infect Dis
. 2015 Mar;
60(10):1512-20.
PMID: 25814628
Background: Herd protection by meningococcal vaccines is conferred by population-level reduction of meningococcal nasopharyngeal colonization. Given the inverse epidemiological association between colonization by commensal Neisseria lactamica and meningococcal disease, we...
9.
Sealey K, Harris S, Fry N, Hurst L, Gorringe A, Parkhill J, et al.
J Infect Dis
. 2014 Dec;
212(2):294-301.
PMID: 25489002
A major outbreak of whooping cough, or pertussis, occurred in 2012 in the United Kingdom (UK), with nearly 10 000 laboratory-confirmed cases and 14 infant deaths attributed to pertussis. A...
10.
Gorringe A, Vaughan T
Expert Rev Vaccines
. 2014 Aug;
13(10):1205-14.
PMID: 25102891
Bordetella pertussis produces two serologically distinct fimbriae, Fim2 and Fim3. Expression of these antigens is governed by the BvgA/S system and by the length of a poly(C) tract in the...