Andrew M White
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Explore the profile of Andrew M White including associated specialties, affiliations and a list of published articles.
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39
Citations
675
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Recent Articles
11.
White A, Palombi I, Malins L
Chem Sci
. 2022 Apr;
13(10):2809-2823.
PMID: 35382479
Umpolung strategies, defined as synthetic approaches which reverse commonly accepted reactivity patterns, are broadly recognized as enabling tools for small molecule synthesis and catalysis. However, methods which exploit this logic...
12.
Clanor P, Buchholz C, Hayes J, Friedman M, White A, Enke R, et al.
Proteins
. 2022 Mar;
90(8):1584-1593.
PMID: 35255174
The cone-rod homeobox (CRX) protein is a critical K50 homeodomain transcription factor responsible for the differentiation and maintenance of photoreceptor neurons in the vertebrate retina. Mutant alleles in the human...
13.
Jakob V, Zoller B, Rinkes J, Wu Y, Kiefer A, Hust M, et al.
Eur J Med Chem
. 2022 Feb;
231:114148.
PMID: 35114538
Small macrocyclic peptides are promising candidates for new anti-infective drugs. To date, such peptides have been poorly studied in the context of anti-virulence targets. Using phage display and a self-designed...
14.
Winters A, Chan W, White A, van den Berg C, Garson M, Cheney K
J Anim Ecol
. 2021 Nov;
91(4):831-844.
PMID: 34839542
Defensive chemicals are used by plants and animals to reduce the risk of predation through different mechanisms, including toxins that cause injury and harm (weapons) and unpalatable or odiferous compounds...
15.
Schlam I, Church S, Hether T, Chaldekas K, Hudson B, White A, et al.
J Transl Med
. 2021 Nov;
19(1):480.
PMID: 34838031
Background: The characterization of the immune component of the tumor microenvironment (TME) of human epidermal growth factor receptor 2 positive (HER2+) breast cancer has been limited. Molecular and spatial characterization...
16.
Durek T, Kaas Q, White A, Weidmann J, Fuaad A, Cheneval O, et al.
J Med Chem
. 2021 Jul;
64(14):9906-9915.
PMID: 34197114
We have designed a new class of highly potent bivalent melanocortin receptor ligands based on the nature-derived bicyclic peptide sunflower trypsin inhibitor 1 (SFTI-1). Incorporation of melanotropin pharmacophores in each...
17.
de Veer S, White A, Craik D
Angew Chem Int Ed Engl
. 2020 Jul;
60(15):8050-8071.
PMID: 32621554
Nature-derived cyclic peptides have proven to be a vast source of inspiration for advancing modern pharmaceutical design and synthetic chemistry. The focus of this Review is sunflower trypsin inhibitor-1 (SFTI-1),...
18.
White A, de Veer S, Wu G, Harvey P, Yap K, King G, et al.
Angew Chem Int Ed Engl
. 2020 Apr;
59(28):11273-11277.
PMID: 32270580
Ruthenium-catalysed azide-alkyne cycloaddition (RuAAC) provides access to 1,5-disubstituted 1,2,3-triazole motifs in peptide engineering applications. However, investigation of this motif as a disulfide mimetic in cyclic peptides has been limited, and...
19.
Sampath D, Lam P, Laoprasert M, Diaz M, Busquet N, White A, et al.
Pediatr Res
. 2020 Jan;
88(2):202-208.
PMID: 31896131
Background: Hypoxia-ischemia (HI) is the most common cause of brain injury in newborns and the survivors often develop cognitive and sensorimotor disabilities that undermine the quality of life. In the...
20.
Yi Li C, de Veer S, White A, Chen X, Harris J, Swedberg J, et al.
J Med Chem
. 2019 Mar;
62(7):3696-3706.
PMID: 30888159
Sunflower trypsin inhibitor-1 (SFTI-1) is a 14-amino acid cyclic peptide that shares an inhibitory loop with a sequence and structure similar to a larger family of serine protease inhibitors, the...