Andrew M White
Overview
Explore the profile of Andrew M White including associated specialties, affiliations and a list of published articles.
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Articles
39
Citations
675
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Recent Articles
1.
Gare C, White A, Malins L
Trends Biochem Sci
. 2025 Feb;
PMID: 40011178
Peptides are a powerful drug modality with potential to access difficult targets. This recognition underlies their growth in the global pharmaceutical market, with peptides representing ~8% of drugs approved by...
2.
Palombi I, White A, Koda Y, Craik D, Lawrence N, Malins L
Chem Biol Drug Des
. 2025 Jan;
105(1):e70051.
PMID: 39834140
Drug targeting strategies, such as peptide-drug conjugates (PDCs), have arisen to combat the issue of off-target toxicity that is commonly associated with chemotherapeutic small molecule drugs. Here we investigated the...
3.
Gare C, Palombi I, White A, Chavchich M, Edstein M, Lock A, et al.
ChemMedChem
. 2024 Oct;
20(2):e202400637.
PMID: 39379289
The devastating impact of malaria includes significant mortality and illness worldwide. Increasing resistance of the causative parasite, Plasmodium, to existing antimalarial drugs underscores a need for additional compounds with distinct...
4.
White A, Schwartz B, Gardiner M, Malins L
Org Lett
. 2024 Jul;
26(32):6803-6808.
PMID: 38968424
The peptide sex-inducing pheromone SIP () bearing an unusual sulfated aspartic acid residue induces sexual reproduction in diatom populations. Herein, we report the first total synthesis of SIP using both...
5.
Koehbach J, Muratspahic E, Ahmed Z, White A, Tomasevic N, Durek T, et al.
RSC Chem Biol
. 2024 Jun;
5(6):567-571.
PMID: 38846076
Cyclotides are a diverse class of plant-derived cyclic, disulfide-rich peptides with a unique cyclic cystine knot topology. Their remarkable structural stability and resistance to proteolytic degradation can lead to improved...
6.
Muratspahic E, Aslanoglou D, White A, Draxler C, Kozisek X, Farooq Z, et al.
ACS Pharmacol Transl Sci
. 2023 Oct;
6(10):1373-1381.
PMID: 37854631
G protein-coupled receptors are among the most widely studied classes of drug targets. A major challenge in this field is to develop ligands that will selectively modulate a single receptor...
7.
Muratspahic E, White A, Ciotu C, Hochrainer N, Tomasevic N, Koehbach J, et al.
J Med Chem
. 2023 Aug;
66(17):11843-11854.
PMID: 37632447
The κ-opioid receptor (KOR) is an attractive target for the development of novel drugs. KOR agonists are potentially safer pain medications, whereas KOR antagonists are promising drug candidates for the...
8.
Palombi I, Lawrence N, White A, Gare C, Craik D, McMorran B, et al.
Bioconjug Chem
. 2023 May;
34(6):1105-1113.
PMID: 37232456
Malaria continues to impose a global health burden. Drug-resistant parasites have emerged to each introduced small-molecule therapy, highlighting the need for novel treatment approaches for the future eradication of malaria....
9.
Shenderov E, De Marzo A, Lotan T, Wang H, Chan S, Lim S, et al.
Nat Med
. 2023 Apr;
29(4):888-897.
PMID: 37012549
B7 homolog 3 (B7-H3; CD276), a tumor-associated antigen and possible immune checkpoint, is highly expressed in prostate cancer (PCa) and is associated with early recurrence and metastasis. Enoblituzumab is a...
10.
White A, Dellsen A, Larsson N, Kaas Q, Jansen F, Plowright A, et al.
J Med Chem
. 2022 Sep;
65(19):12956-12969.
PMID: 36167503
In this work, cysteine staples were used as a late-stage functionalization strategy to diversify peptides and build conjugates targeting the melanocortin G-protein-coupled receptors [melanocortin receptor-1 (MC1R) and MC3R-MC5R]. Monocyclic and...