Andrew M Schumacher
Overview
Explore the profile of Andrew M Schumacher including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
614
Followers
0
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Recent Articles
1.
Searleman A, Ma Y, Sampath S, Sampath S, Bussell R, Chang E, et al.
Front Neuroimaging
. 2024 May;
3():1356713.
PMID: 38783990
Purpose: To test the ability of inversion-recovery ultrashort echo time (IR-UTE) MRI to directly detect demyelination in mice using a standard cuprizone mouse model. Methods: Non-aqueous myelin protons have ultrashort...
2.
Liu Y, Jin Q, Ding Q, Hao X, Mo T, Yan S, et al.
ChemMedChem
. 2020 Jul;
15(16):1562-1570.
PMID: 32613743
Loss of β-cell mass and function can lead to insufficient insulin levels and ultimately to hyperglycemia and diabetes mellitus. The mainstream treatment approach involves regulation of insulin levels; however, approaches...
3.
Liu Y, Jin Q, Zou Y, Ding Q, Yan S, Wang Z, et al.
J Med Chem
. 2020 Feb;
63(6):2958-2973.
PMID: 32077280
Autoimmune deficiency and destruction in either β-cell mass or function can cause insufficient insulin levels and, as a result, hyperglycemia and diabetes. Thus, promoting β-cell proliferation could be one approach...
4.
Cheng H, Deaton L, Qiu M, Ha S, Pacoma R, Lao J, et al.
Neurobiol Dis
. 2019 Nov;
134:104683.
PMID: 31765727
Repeated mild traumatic brain injury (rmTBI) can lead to development of chronic traumatic encephalopathy (CTE), which is characterized by progressive neurodegeneration with presence of white matter damage, gliosis and hyper-phosphorylated...
5.
Cheung S, Miller M, Pacoma R, Roland J, Liu J, Schumacher A, et al.
ACS Chem Biol
. 2017 Nov;
12(12):3126-3133.
PMID: 29099173
Glycosaminoglycans (GAGs) play critical roles in diverse processes ranging from viral infection to neuroregeneration. Their regiospecific sulfation patterns, which are generated by sulfotransferases, are key structural determinants that underlie their...
6.
Carson C, Raman P, Tullai J, Xu L, Henault M, Thomas E, et al.
PLoS One
. 2015 Jun;
10(6):e0127498.
PMID: 26098886
Englerin A is a structurally unique natural product reported to selectively inhibit growth of renal cell carcinoma cell lines. A large scale phenotypic cell profiling experiment (CLiP) of englerin A...
7.
Syeda R, Xu J, Dubin A, Coste B, Mathur J, Huynh T, et al.
Elife
. 2015 May;
4.
PMID: 26001275
Piezo ion channels are activated by various types of mechanical stimuli and function as biological pressure sensors in both vertebrates and invertebrates. To date, mechanical stimuli are the only means...
8.
Rooney L, Vidal A, DSouza A, Devereux N, Masick B, Boissel V, et al.
J Med Chem
. 2014 Jun;
57(12):5129-40.
PMID: 24884675
A high throughput screening campaign identified 5-(2-chlorophenyl)indazole compound 4 as an antagonist of the transient receptor potential A1 (TRPA1) ion channel with IC50 = 1.23 μM. Hit to lead medicinal...
9.
Walker J, Pacoma R, Watson J, Ou W, Alves J, Mason D, et al.
J Neurosci
. 2013 Feb;
33(6):2457-64.
PMID: 23392674
Accumulation of β-amyloid (Aβ) in the brain is believed to contribute to the pathology of Alzheimer's Disease (AD). Aβ levels are controlled by the production of Aβ from amyloid precursor...
10.
Owen K, Qiu D, Alves J, Schumacher A, Kilpatrick L, Li J, et al.
Biochem J
. 2009 Dec;
426(2):219-28.
PMID: 20015050
HGF (hepatocyte growth factor) is a pleiotropic cytokine homologous to the serine protease zymogen plasminogen that requires canonical proteolytic cleavage to gain functional activity. The activating proteases are key components...