D Martin Watterson
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Explore the profile of D Martin Watterson including associated specialties, affiliations and a list of published articles.
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Articles
78
Citations
2444
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Recent Articles
1.
Acquarone E, Argyrousi E, Arancio O, Watterson D, Roy S
J Alzheimers Dis
. 2024 Apr;
98(4):1349-1360.
PMID: 38578894
Background: Background: Neurodegenerative diseases manifest behavioral dysfunction with disease progression. Intervention with neuropsychiatric drugs is part of most multi-drug treatment paradigms. However, only a fraction of patients responds to the...
2.
Schmid M, Kang S, Chen H, Paradise M, Ghebremedhin A, Kaneda M, et al.
Nat Commun
. 2022 Apr;
13(1):1768.
PMID: 35365657
Myeloid cells play key roles in cancer immune suppression and tumor progression. In response to tumor derived factors, circulating monocytes and granulocytes extravasate into the tumor parenchyma where they stimulate...
3.
Braun D, Powell D, McLouth C, Roy S, Watterson D, Van Eldik L
PLoS One
. 2022 Jan;
17(1):e0262474.
PMID: 35081152
Alzheimer's disease (AD) is the leading cause of dementia in the elderly, but therapeutic options are lacking. Despite long being able to effectively treat the ill-effects of pathology present in...
4.
Khapchaev A, Watterson D, Shirinsky V
Biochim Biophys Acta Mol Cell Res
. 2021 Jul;
1868(11):119104.
PMID: 34302892
Background: Myosin light chain kinase (MLCK) is a Ca-calmodulin-dependent enzyme dedicated to phosphorylate and activate myosin II to provide force for various motile processes. In smooth muscle cells and many...
5.
Roy S, Minasov G, Arancio O, Chico L, Van Eldik L, Anderson W, et al.
J Med Chem
. 2020 Jul;
63(15):8649.
PMID: 32672466
No abstract available.
6.
Van Eldik L, Sawaki L, Bowen K, Laskowitz D, Noveck R, Hauser B, et al.
Clin Pharmacol Drug Dev
. 2020 Apr;
10(2):131-143.
PMID: 32255549
MW01-6-189WH (MW189) is a novel central nervous system-penetrant small-molecule drug candidate that selectively attenuates stressor-induced proinflammatory cytokine overproduction and is efficacious in intracerebral hemorrhage and traumatic brain injury animal models....
7.
Simon C, Van Alstyne M, Lotti F, Bianchetti E, Tisdale S, Watterson D, et al.
Cell Rep
. 2019 Dec;
29(12):3885-3901.e5.
PMID: 31851921
Reduced expression of the survival motor neuron (SMN) protein causes the neurodegenerative disease spinal muscular atrophy (SMA). Here, we show that adeno-associated virus serotype 9 (AAV9)-mediated delivery of Stasimon-a gene...
8.
Braun D, Bachstetter A, Sudduth T, Wilcock D, Watterson D, Van Eldik L
Geroscience
. 2019 May;
41(5):671-679.
PMID: 31104189
The blood-brain barrier (BBB) is critical in maintenance of brain homeostasis, and loss of its functional integrity is a key feature across a broad range of neurological insults. This includes...
9.
Roy S, Minasov G, Arancio O, Chico L, Van Eldik L, Anderson W, et al.
J Med Chem
. 2019 Apr;
62(11):5298-5311.
PMID: 30978288
The p38αMAPK is a serine/threonine protein kinase and a key node in the intracellular signaling networks that transduce and amplify stress signals into physiological changes. A preponderance of preclinical data...
10.
Robson M, Quinlan M, Margolis K, Gajewski-Kurdziel P, Veenstra-VanderWeele J, Gershon M, et al.
Proc Natl Acad Sci U S A
. 2018 Oct;
115(43):E10245-E10254.
PMID: 30297392
Autism spectrum disorder (ASD) is a common neurobehavioral disorder with limited treatment options. Activation of p38 MAPK signaling networks has been identified in ASD, and p38 MAPK signaling elevates serotonin...