Andrew L Paek
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Explore the profile of Andrew L Paek including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
304
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Recent Articles
1.
Jose E, Paek A
Methods Mol Biol
. 2024 Nov;
2871:131-143.
PMID: 39565584
FOXO transcription factors respond to a number of different stresses by shuttling from the cytoplasm to the nucleus where they upregulate hundreds of target genes with diverse cellular functions. The...
2.
Escoto A, Hecksel R, Parkinson C, Crane S, Atwell B, King S, et al.
Oncogene
. 2024 Nov;
44(5):288-295.
PMID: 39521886
Natural Killer (NK) cells can target and destroy cancer cells, yet tumor microenvironments typically suppress NK cell recruitment and cytotoxicity. The epidermal growth factor receptor (EGFR) is a potent oncogene...
3.
Cabel C, Guzman B, Alizadeh E, Li S, Holberg C, Wichaidit C, et al.
bioRxiv
. 2024 Oct;
PMID: 39416139
The sudden rise of the SARS-CoV-2 virus and the delay in the development of effective therapeutics to mitigate it made evident a need for ways to screen for compounds that...
4.
Jose E, March-Steinman W, Wilson B, Shanks L, Parkinson C, Alvarado-Cruz I, et al.
Nat Commun
. 2024 Apr;
15(1):3440.
PMID: 38653977
Oxidative stress from excess HO activates transcription factors that restore redox balance and repair oxidative damage. Although many transcription factors are activated by HO, it is unclear whether they are...
5.
Jose E, March-Steinman W, Wilson B, Shanks L, Paek A
bioRxiv
. 2023 Mar;
PMID: 36945409
The p53 and FOXO transcription factors (TFs) share many similarities despite their distinct evolutionary origins. Both TFs are activated by a variety of cellular stresses and upregulate genes in similar...
6.
Lasick K, Jose E, Samayoa A, Shanks L, Pond K, Thorne C, et al.
Mol Biol Cell
. 2023 Feb;
34(3):ar21.
PMID: 36735481
FOXO transcription factors are regulators of cellular homeostasis linked to increased lifespan and tumor suppression. FOXOs are activated by diverse cell stresses including serum starvation and oxidative stress. FOXO activity...
7.
Cantoria M, Alizadeh E, Ravi J, Varghese R, Bunnag N, Pond K, et al.
Proc Natl Acad Sci U S A
. 2023 Jan;
120(2):e2208787120.
PMID: 36598937
Wnt ligands are considered classical morphogens, for which the strength of the cellular response is proportional to the concentration of the ligand. Herein, we show an emergent property of bistability...
8.
Pond K, Morris J, Alkhimenok O, Varghese R, Cabel C, Ellis N, et al.
Elife
. 2022 Sep;
11.
PMID: 36094159
The establishment and maintenance of different cellular compartments in tissues is a universal requirement across all metazoans. Maintaining the correct ratio of cell types in time and space allows tissues...
9.
Zhang Y, Huynh J, Liu G, Ballweg R, Aryeh K, Paek A, et al.
PLoS Comput Biol
. 2019 Sep;
15(9):e1007158.
PMID: 31498788
Chemotherapy resistance is a major challenge to the effective treatment of cancer. Thus, a systematic pipeline for the efficient identification of effective combination treatments could bring huge biomedical benefit. In...
10.
Chakrabarti S, Paek A, Reyes J, Lasick K, Lahav G, Michor F
Nat Commun
. 2018 Dec;
9(1):5372.
PMID: 30560953
The origin of lineage correlations among single cells and the extent of heterogeneity in their intermitotic times (IMT) and apoptosis times (AT) remain incompletely understood. Here we developed single cell...