Andrew Jaffe
Overview
Explore the profile of Andrew Jaffe including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
594
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0
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Recent Articles
1.
Redd A, Peetluk L, Jarrett B, Hanrahan C, Schwartz S, Rao A, et al.
medRxiv
. 2021 May;
PMID: 33948611
The public health crisis created by the SARS-CoV-2 pandemic has spurred a deluge of scientific research aimed at informing public health and medical response to the COVID-19 pandemic. However, those...
2.
Lin C, Chang L, Ma T, Oh H, French B, Puralewski R, et al.
Mol Psychiatry
. 2020 Jul;
26(7):3646-3656.
PMID: 32632206
Psychiatric disorders are associated with accelerated aging and enhanced risk for neurodegenerative disorders. Brain aging is associated with molecular, cellular, and structural changes that are robust on the group level,...
3.
Ren M, Hu Z, Chen Q, Jaffe A, Li Y, Sadashivaiah V, et al.
Mol Psychiatry
. 2019 Oct;
25(1):206-229.
PMID: 31570775
Increased expression of the 3.1 isoform of the KCNH2 potassium channel has been associated with cognitive dysfunction and with schizophrenia, yet little is known about the underlying pathophysiological mechanisms. Here,...
4.
Ellis S, Collado-Torres L, Jaffe A, Leek J
Nucleic Acids Res
. 2018 Mar;
46(9):e54.
PMID: 29514223
Publicly available genomic data are a valuable resource for studying normal human variation and disease, but these data are often not well labeled or annotated. The lack of phenotype information...
5.
Association of DNA Methylation Differences With Schizophrenia in an Epigenome-Wide Association Study
Montano C, Taub M, Jaffe A, Briem E, Feinberg J, Trygvadottir R, et al.
JAMA Psychiatry
. 2016 Apr;
73(5):506-14.
PMID: 27074206
Importance: DNA methylation may play an important role in schizophrenia (SZ), either directly as a mechanism of pathogenesis or as a biomarker of risk. Objective: To scan genome-wide DNA methylation...
6.
Schwartzman A, Jaffe A, Gavrilov Y, Meyer C
Ann Appl Stat
. 2014 Nov;
7(1):471-494.
PMID: 25411587
A topological multiple testing approach to peak detection is proposed for the problem of detecting transcription factor binding sites in ChIP-Seq data. After kernel smoothing of the tag counts over...
7.
Michailidi C, Soudry E, Brait M, Maldonado L, Jaffe A, Ili-Gangas C, et al.
Gastroenterol Res Pract
. 2014 May;
2014:597164.
PMID: 24829571
The majority of the epigenomic reports in hepatocellular carcinoma have focused on identifying novel differentially methylated drivers or passengers of the oncogenic process. Few reports have considered the technologies in...
8.
Fertig E, Stein-OBrien G, Jaffe A, Colantuoni C
Methods Mol Biol
. 2013 Nov;
1101:87-112.
PMID: 24233779
Patterns in time-course gene expression data can represent the biological processes that are active over the measured time period. However, the orthogonality constraint in standard pattern-finding algorithms, including notably principal...
9.
Jaffe A, Wojcik G, Chu A, Golozar A, Maroo A, Duggal P, et al.
BMC Proc
. 2012 Mar;
5 Suppl 9:S13.
PMID: 22373437
Recent technological advances have allowed us to study individual genomes at a base-pair resolution and have demonstrated that the average exome harbors more than 15,000 genetic variants. However, our ability...
10.
Vincent A, Omura N, Hong S, Jaffe A, Eshleman J, Goggins M
Clin Cancer Res
. 2011 May;
17(13):4341-54.
PMID: 21610144
Purpose: The goal of this study was to comprehensively identify CpG island methylation alterations between pancreatic cancers and normal pancreata and their associated gene expression alterations. Experimental Design: We employed...