Andrew J Andrews
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Explore the profile of Andrew J Andrews including associated specialties, affiliations and a list of published articles.
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41
Citations
1660
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Recent Articles
1.
Makhov P, Fazliyeva R, Tufano A, Uzzo R, Cai K, Serebriiskii I, et al.
Cancers (Basel)
. 2022 Dec;
14(23).
PMID: 36497382
The commonly used therapeutic management of PC involves androgen deprivation therapy (ADT) followed by treatment with AR signaling inhibitors (ARSI). However, nearly all patients develop drug-resistant disease, with a median...
2.
Pandey S, Djibo R, Darracq A, Calendo G, Zhang H, Henry R, et al.
Cancers (Basel)
. 2022 Jul;
14(14).
PMID: 35884401
Aberrant transcription in cancer cells involves the silencing of tumor suppressor genes (TSGs) and activation of oncogenes. Transcriptomic changes are associated with epigenomic alterations such as DNA-hypermethylation, histone deacetylation, and...
3.
Lowe B, Yadav R, Henry R, Schreiner P, Matsuda A, Fernandez A, et al.
Elife
. 2021 Feb;
10.
PMID: 33522486
Sequencing of cancer genomes has identified recurrent somatic mutations in histones, termed oncohistones, which are frequently poorly understood. Previously we showed that fission yeast expressing only the H3.3G34R mutant identified...
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5.
Discordant Effects of Putative Lysine Acetyltransferase Inhibitors in Biochemical and Living Systems
Henry R, Kuo Y, Siegel Z, Yen T, Rhodes J, Taylor E, et al.
Cells
. 2019 Sep;
8(9).
PMID: 31480793
Lysine acetyltransferases (KATs) are exquisitely fine-tuned to target specific lysine residues on many proteins, including histones, with aberrant acetylation at distinct lysines implicated in different pathologies. However, researchers face a...
6.
Cote J, Kuo Y, Henry R, Scherman H, Krzizike D, Andrews A
Nucleic Acids Res
. 2019 Jun;
47(14):7380-7391.
PMID: 31194870
The ability of histone chaperone Anti-silencing factor 1 (Asf1) to direct acetylation of lysine 56 of histone H3 (H3K56ac) represents an important regulatory step in genome replication and DNA repair....
7.
Sidoli S, Kori Y, Lopes M, Yuan Z, Kim H, Kulej K, et al.
Genome Res
. 2019 May;
29(6):978-987.
PMID: 31123082
DNA and histone proteins define the structure and composition of chromatin. Histone posttranslational modifications (PTMs) are covalent chemical groups capable of modeling chromatin accessibility, mostly due to their ability in...
8.
Duong-Ly K, Kuo Y, Johnson M, Cote J, Kollman J, Soboloff J, et al.
J Cell Sci
. 2018 Aug;
131(17).
PMID: 30154209
T cell-mediated adaptive immunity requires naïve, unstimulated T cells to transition from a quiescent metabolic state into a highly proliferative state upon T cell receptor engagement. This complex process depends...
9.
Lee H, Wang L, Kuo Y, Andrews A, Gupta S, Kruger W
Mol Genet Metab Rep
. 2018 Jul;
15:15-21.
PMID: 30023284
Elevated plasma total homocysteine (tHcy) is associated with a number of human diseases including coronary artery disease, stroke, osteoporosis and dementia. It is highly correlated with intracellular S-adenosylhomocysteine (SAH). Since...
10.
Gordon R, Zhang L, Peri S, Kuo Y, Du F, Egleston B, et al.
Clin Cancer Res
. 2018 Feb;
24(6):1375-1388.
PMID: 29437795
The role of cholesterol biosynthesis in hedgehog pathway activity and progression of hedgehog pathway medulloblastoma (Hh-MB) were examined Statins, commonly used cholesterol-lowering agents, were utilized to validate cholesterol biosynthesis as...