Roozbeh Eskandari
Overview
Explore the profile of Roozbeh Eskandari including associated specialties, affiliations and a list of published articles.
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14
Citations
240
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Recent Articles
1.
Shi C, Eskandari R, Zhang J, Zhang G, Li L, Hawkins D, et al.
Proc Natl Acad Sci U S A
. 2025 Feb;
122(6):e2415039122.
PMID: 39899708
Lipid peroxidation is a complex biochemical process associated with oxidative stress, and its products play crucial roles in cellular signaling and the pathophysiology of many diseases. Among the diverse array...
2.
Wagner A, Lang T, Ledingham E, Ghosh A, Brooks D, Eskandari R, et al.
J Med Chem
. 2025 Jan;
68(3):3653-3672.
PMID: 39818772
DNPH1 is responsible for eliminating the epigenetically modified nucleotide, 5-hydroxymethyl-2'-deoxyuridine 5'-monophosphate (hmdUMP), preventing formation of hmdUTP, a mutation-inducing nucleotide. Loss of DNPH1 activity sensitizes PARP inhibition-resistant BRCA-deficient cancers by causing...
3.
Marin-Valencia I, Kocabas A, Rodriguez-Navas C, Miloushev V, Gonzalez-Rodriguez M, Lees H, et al.
Cell Metab
. 2024 Jun;
36(6):1394-1410.e12.
PMID: 38838644
A vexing problem in mitochondrial medicine is our limited capacity to evaluate the extent of brain disease in vivo. This limitation has hindered our understanding of the mechanisms that underlie...
4.
Wagner A, Eskandari R, Schramm V
Anal Biochem
. 2023 May;
672:115171.
PMID: 37142196
2'-Deoxynucleoside 5'-monophosphate N-glycosidase 1 (DNPH1) hydrolyzes the epigenetically modified nucleotide 5-hydroxymethyl 2'-deoxyuridine 5'-monophosphate (hmdUMP) derived from DNA metabolism. Published assays of DNPH1 activity are low throughput, use high concentrations of...
5.
Eskandari R, Kim N, Mamakhanyan A, Saoi M, Zhang G, Berisaj M, et al.
Proc Natl Acad Sci U S A
. 2022 May;
119(19):e2120595119.
PMID: 35512101
Glutamine is consumed by rapidly proliferating cells and can provide the carbon and nitrogen required for growth through various metabolic pathways. However, delineating the metabolic fate of glutamine is challenging...
6.
Tee S, Kim N, Cullen Q, Eskandari R, Mamakhanyan A, Srouji R, et al.
Sci Adv
. 2022 Apr;
8(14):eabm7985.
PMID: 35385296
The ability to break down fructose is dependent on ketohexokinase (KHK) that phosphorylates fructose to fructose-1-phosphate (F1P). We show that KHK expression is tightly controlled and limited to a small...
7.
Eskandari R, Hess J, Tochtrop G
Chem Commun (Camb)
. 2021 Jun;
57(58):7136-7139.
PMID: 34180477
Herein, a new protocol for rapid synthesis of α,β-unsaturated epoxy ketones utilizing a bifunctional sulfonium/phosphonium ylide is described. This approach comprises two sequential chemoselective reactions between sulfonium and phosphonium ylides...
8.
Lees H, Millan M, Ahamed F, Eskandari R, Granlund K, Jeong S, et al.
NMR Biomed
. 2020 Dec;
34(3):e4447.
PMID: 33314422
Hyperpolarized [1- C] pyruvate can be used to examine the metabolic state of cancer cells, highlighting a key metabolic characteristic of cancer: the upregulated metabolic flux to lactate, even in...
9.
Deh K, Granlund K, Eskandari R, Kim N, Mamakhanyan A, Keshari K
Magn Reson Med
. 2020 Aug;
85(2):978-986.
PMID: 32820566
Purpose: To generate dynamic, volumetric maps of hyperpolarized [1- C]pyruvate and its metabolic products in vivo. Methods: Maps of chemical species were generated with iterative least squares (IDEAL) reconstruction from...
10.
Ngo B, Kim E, Osorio-Vasquez V, Doll S, Bustraan S, Liang R, et al.
Cancer Discov
. 2020 Jun;
10(9):1352-1373.
PMID: 32571778
A hallmark of metastasis is the adaptation of tumor cells to new environments. Metabolic constraints imposed by the serine and glycine-limited brain environment restrict metastatic tumor growth. How brain metastases...