Andrew G Roberts
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Explore the profile of Andrew G Roberts including associated specialties, affiliations and a list of published articles.
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26
Citations
111
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Recent Articles
1.
Nguyen J, da Hora G, Mifflin M, Roberts A, Swanson J
bioRxiv
. 2025 Feb;
PMID: 39896618
Significance: Lasso peptides are a unique class of ribosomally synthesized and post-translationally modified natural products with diverse biological activities and potential for therapeutic applications. Although direct synthesis would facilitate therapeutic...
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Bender A, Holiski C, Embree M, Hennkens H, Klaehn J, Lundgreen E, et al.
Sens Diagn
. 2024 Nov;
4(1):35-43.
PMID: 39493501
Theranostics is a field of nuclear medicine which uses the same targeting vector and chelating system for both a diagnostic and therapeutic radionuclide, allowing for uniformity in imaging and treatment....
4.
Bender A, Kirkeby E, Cross D, Minoshima S, Roberts A, Mastren T
J Nucl Med
. 2024 Jul;
65(9):1467-1472.
PMID: 39054283
Alzheimer disease is a neurodegenerative disorder with limited treatment options. It is characterized by the presence of several biomarkers, including amyloid-β aggregates, which lead to oxidative stress and neuronal decay....
5.
Keyes E, Mifflin M, Austin M, Sandres J, Roberts A
Methods Enzymol
. 2024 Jun;
698:89-109.
PMID: 38886041
Tyr-derived cyclic peptide natural products are formed by enzymatic manifolds that oxidatively cross-link embedded phenolic side chains of tyrosine (Tyr) and 4-hydroxyphenylglycine residues during their controlled production. Bioactive Tyr-derived cyclic...
6.
da Hora G, Oh M, Mifflin M, Digal L, Roberts A, Swanson J
J Am Chem Soc
. 2024 Jan;
146(7):4444-4454.
PMID: 38166378
Lasso peptides make up a class of natural products characterized by a threaded structure. Given their small size and stability, chemical synthesis would offer tremendous potential for the development of...
7.
Eastman K, Mifflin M, Oblad P, Roberts A, Bandarian V
ACS Bio Med Chem Au
. 2023 Dec;
3(6):480-493.
PMID: 38144258
Ribosomally produced and post-translationally modified polypeptides (RiPPs) are a diverse group of natural products that are processed by a variety of enzymes to their biologically relevant forms. PapB is a...
8.
Digal L, Samson S, Stevens M, Ghorai A, Kim H, Mifflin M, et al.
ACS Chem Biol
. 2023 Dec;
19(1):81-88.
PMID: 38109560
Lasso peptides are a structurally distinct class of biologically active natural products defined by their short sequences with impressively interlocked tertiary structures. Their characteristic peptide [1]rotaxane motif confers marked proteolytic...
9.
Wallace M, Cummings Jr D, Roberts A, Puri A
mBio
. 2023 Dec;
15(1):e0199923.
PMID: 38085021
Bacteria known as pink-pigmented facultative methylotrophs colonize many diverse environments on earth, play an important role in the carbon cycle, and in some cases promote plant growth. However, little is...
10.
Kirkeby E, Schwartz Z, Lovasz M, Roberts A
Chem Sci
. 2023 Oct;
14(38):10508-10514.
PMID: 37800000
A concise strategy to prepare polycyclic heteroaromatics involving a deaminative contraction cascade is detailed. The efficient deaminative ring contraction involves the methylation of a biaryl-linked dihydroazepine to form a cyclic...