Marcus C Mifflin
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Explore the profile of Marcus C Mifflin including associated specialties, affiliations and a list of published articles.
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5
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10
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Recent Articles
1.
Nguyen J, da Hora G, Mifflin M, Roberts A, Swanson J
bioRxiv
. 2025 Feb;
PMID: 39896618
Significance: Lasso peptides are a unique class of ribosomally synthesized and post-translationally modified natural products with diverse biological activities and potential for therapeutic applications. Although direct synthesis would facilitate therapeutic...
2.
Keyes E, Mifflin M, Austin M, Sandres J, Roberts A
Methods Enzymol
. 2024 Jun;
698:89-109.
PMID: 38886041
Tyr-derived cyclic peptide natural products are formed by enzymatic manifolds that oxidatively cross-link embedded phenolic side chains of tyrosine (Tyr) and 4-hydroxyphenylglycine residues during their controlled production. Bioactive Tyr-derived cyclic...
3.
da Hora G, Oh M, Mifflin M, Digal L, Roberts A, Swanson J
J Am Chem Soc
. 2024 Jan;
146(7):4444-4454.
PMID: 38166378
Lasso peptides make up a class of natural products characterized by a threaded structure. Given their small size and stability, chemical synthesis would offer tremendous potential for the development of...
4.
Eastman K, Mifflin M, Oblad P, Roberts A, Bandarian V
ACS Bio Med Chem Au
. 2023 Dec;
3(6):480-493.
PMID: 38144258
Ribosomally produced and post-translationally modified polypeptides (RiPPs) are a diverse group of natural products that are processed by a variety of enzymes to their biologically relevant forms. PapB is a...
5.
Digal L, Samson S, Stevens M, Ghorai A, Kim H, Mifflin M, et al.
ACS Chem Biol
. 2023 Dec;
19(1):81-88.
PMID: 38109560
Lasso peptides are a structurally distinct class of biologically active natural products defined by their short sequences with impressively interlocked tertiary structures. Their characteristic peptide [1]rotaxane motif confers marked proteolytic...
6.
Keyes E, Mifflin M, Austin M, Alvey B, Lovely L, Smith A, et al.
J Am Chem Soc
. 2023 Apr;
145(18):10071-10081.
PMID: 37119237
Inspired by nature's wide range of oxidation-induced modifications to install cross-links and cycles at tyrosine (Tyr) and other phenol-containing residue side chains, we report a Tyr-selective strategy for the preparation...