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Andrew D Randall

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Recent Articles
1.
Brady E, Griffiths J, Andrianova L, Bielska M, Saito T, Saido T, et al.
Neurobiol Dis . 2023 May; 182:106151. PMID: 37172910
In the early stages of Alzheimer's disease (AD), the accumulation of the peptide amyloid-β (Aβ) damages synapses and disrupts neuronal activity, leading to the disruption of neuronal oscillations associated with...
2.
Potter P, Ellacott K, Randall A, Beall C
Cells . 2022 Nov; 11(21). PMID: 36359822
Astrocytes contribute to glutamatergic signalling, which is required for hypoglycaemia counterregulation and is impaired by recurrent insulin-induced hypoglycaemia. This study examined the glutamate response of astrocytes when challenged with acute...
3.
Walsh C, Ridler T, Margetts-Smith G, Garrido M, Witton J, Randall A, et al.
J Neurosci . 2022 Aug; 42(37):7094-7109. PMID: 35927034
The retrosplenial cortex (RSC) plays a significant role in spatial learning and memory and is functionally disrupted in the early stages of Alzheimer's disease (AD). In order to investigate neurophysiological...
4.
Pinion J, Walsh C, Goodfellow M, Randall A, Tyler C, Winter M
eNeuro . 2022 Mar; 9(2). PMID: 35228313
We assessed similarities and differences in the electrographic signatures of local field potentials (LFPs) evoked by different pharmacological agents in zebrafish larvae. We then compared and contrasted these characteristics with...
5.
Winter M, Pinion J, Tochwin A, Takesono A, Ball J, Grabowski P, et al.
Br J Pharmacol . 2021 Mar; 178(13):2671-2689. PMID: 33768524
Background And Purpose: Functional brain imaging using genetically encoded Ca sensors in larval zebrafish is being developed for studying seizures and epilepsy as a more ethical alternative to rodent models....
6.
Ridler T, Witton J, Phillips K, Randall A, Brown J
Elife . 2020 Nov; 9. PMID: 33242304
Dementia is associated with severe spatial memory deficits which arise from dysfunction in hippocampal and parahippocampal circuits. For spatially sensitive neurons, such as grid cells, to faithfully represent the environment...
7.
Stathakos P, Jimenez-Moreno N, Crompton L, Nistor P, Badger J, Barbuti P, et al.
Autophagy . 2020 Apr; 17(4):855-871. PMID: 32286126
Macroautophagy/autophagy cytoplasmic quality control pathways are required during neural development and are critical for the maintenance of functional neuronal populations in the adult brain. Robust evidence now exists that declining...
8.
Walsh D, Brown J, Randall A
Neurobiol Aging . 2020 Feb; 88:1-10. PMID: 32065917
Recently, increased neuronal activity in nucleus reuniens (Re) has been linked to hyperexcitability within hippocampal-thalamo-cortical networks in the J20 mouse model of amyloidopathy. Here in vitro whole-cell patch clamp recordings...
9.
Smithers H, Terry J, Brown J, Randall A
Neurobiol Stress . 2019 Apr; 10:100143. PMID: 30937349
The bed nucleus of the stria terminalis (BNST) is a sexually dimorphic brain region which plays a key role in stress, anxiety, and anxiety-related disorders. Human females have an increased...
10.
Winter M, Windell D, Metz J, Matthews P, Pinion J, Brown J, et al.
Sci Rep . 2018 Oct; 8(1):15903. PMID: 30349014
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