Andrew D Huber
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Explore the profile of Andrew D Huber including associated specialties, affiliations and a list of published articles.
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Articles
39
Citations
431
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Recent Articles
31.
Kirby K, Myshakina N, Christen M, Chen Y, Schmidt H, Huber A, et al.
Antimicrob Agents Chemother
. 2017 Aug;
61(10).
PMID: 28760905
The RNase H (RNH) function of HIV-1 reverse transcriptase (RT) plays an essential part in the viral life cycle. We report the characterization of YLC2-155, a 2-hydroxyisoquinoline-1,3-dione (HID)-based active-site RNH...
32.
Vernekar S, Tang J, Wu B, Huber A, Casey M, Myshakina N, et al.
J Med Chem
. 2017 May;
60(12):5045-5056.
PMID: 28525279
Human immunodeficiency virus (HIV) reverse transcriptase (RT)-associated ribonuclease H (RNase H) remains the only virally encoded enzymatic function yet to be exploited as an antiviral target. One of the possible...
33.
Tang J, Vernekar S, Chen Y, Miller L, Huber A, Myshakina N, et al.
Eur J Med Chem
. 2017 Apr;
133:85-96.
PMID: 28384548
Human immunodeficiency virus (HIV) reverse transcriptase (RT) associated ribonuclease H (RNase H) remains the only virally encoded enzymatic function not clinically validated as an antiviral target. 2-Hydroxyisoquinoline-1,3-dione (HID) is known...
34.
Huber A, Michailidis E, Tang J, Puray-Chavez M, Boftsi M, Wolf J, et al.
Antimicrob Agents Chemother
. 2017 Mar;
61(6).
PMID: 28320718
Hepatitis B virus (HBV) RNase H (RNH) is an appealing therapeutic target due to its essential role in viral replication. RNH inhibitors (RNHIs) could help to more effectively control HBV...
35.
Tang J, Kirby K, Huber A, Casey M, Ji J, Wilson D, et al.
Eur J Med Chem
. 2017 Feb;
128:168-179.
PMID: 28182989
3-Hydroxypyrimidine-2,4-dione (HPD) represents a versatile chemical core in the design of inhibitors of human immunodeficiency virus (HIV) reverse transcriptase (RT)-associated RNase H and integrase strand transfer (INST). We report herein...
36.
Wu B, Tang J, Wilson D, Huber A, Casey M, Ji J, et al.
J Med Chem
. 2016 Jun;
59(13):6136-48.
PMID: 27283261
Resistance selection by human immunodeficiency virus (HIV) toward known drug regimens necessitates the discovery of structurally novel antivirals with a distinct resistance profile. On the basis of our previously reported...
37.
Michailidis E, Huber A, Ryan E, Ong Y, Leslie M, Matzek K, et al.
J Biol Chem
. 2014 Jun;
289(35):24533-48.
PMID: 24970894
4'-Ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) is a nucleoside analog that, unlike approved anti-human immunodeficiency virus type 1 (HIV-1) nucleoside reverse transcriptase inhibitors, has a 3'-OH and exhibits remarkable potency against wild-type and drug-resistant...
38.
Huber A, Michailidis E, Schultz M, Ong Y, Bloch N, Puray-Chavez M, et al.
Antimicrob Agents Chemother
. 2014 May;
58(8):4915-9.
PMID: 24867973
Sterile alpha motif- and histidine/aspartic acid domain-containing protein 1 (SAMHD1) limits HIV-1 replication by hydrolyzing deoxynucleoside triphosphates (dNTPs) necessary for reverse transcription. Nucleoside reverse transcriptase inhibitors (NRTIs) are components of...
39.
Michailidis E, Ryan E, Hachiya A, Kirby K, Marchand B, Leslie M, et al.
Retrovirology
. 2013 Jun;
10:65.
PMID: 23800377
Background: The K65R substitution in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) is the major resistance mutation selected in patients treated with first-line antiretroviral tenofovir disoproxil fumarate (TDF)....