Andrew D Cook
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Explore the profile of Andrew D Cook including associated specialties, affiliations and a list of published articles.
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52
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2588
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Recent Articles
1.
Lupancu T, Lee K, Eivazitork M, Hor C, Fleetwood A, Cook A, et al.
iScience
. 2023 Oct;
26(10):108079.
PMID: 37860753
Glucocorticoids (GCs) are potent anti-inflammatory agents and are broadly used in treating rheumatoid arthritis (RA) patients, albeit with adverse side effects associated with long-term usage. The negative consequences of GC...
2.
Lee K, Zhang Z, Achuthan A, Fleetwood A, Smith J, Hamilton J, et al.
Arthritis Res Ther
. 2020 May;
22(1):123.
PMID: 32471485
Background: The cytokine, interleukin-23 (IL-23), can be critical for the progression of inflammatory diseases, including arthritis, and is often associated with T lymphocyte biology. We previously showed that certain lymphocyte-independent,...
3.
Tewari D, Cook A, Lee M, Christensen A, Croxford A, Becher B, et al.
J Neurosci
. 2020 Feb;
40(11):2189-2199.
PMID: 32019828
The interaction between the immune system and the nervous system has been at the center of multiple research studies in recent years. Whereas the role played by cytokines as neuronal...
4.
de Souza D, Achuthan A, Lee M, Binger K, Lee M, Davidson S, et al.
J Clin Invest
. 2019 Sep;
129(10):4239-4244.
PMID: 31483287
Macrophage activation in response to LPS is coupled to profound metabolic changes, typified by accumulation of the TCA cycle intermediates citrate, itaconate, and succinate. We have identified that endogenous type...
5.
Conaghan P, Cook A, Hamilton J, Tak P
Nat Rev Rheumatol
. 2019 May;
15(6):355-363.
PMID: 31068673
Pain is the major symptom of osteoarthritis (OA) and is an important factor in strategies to manage this disease. However, the current standard of care does not provide satisfactory pain...
6.
Lee M, Lacey D, Fleetwood A, Achuthan A, Hamilton J, Cook A
J Immunol
. 2019 Apr;
202(10):3033-3040.
PMID: 30988114
Studies have demonstrated the importance of a GM-CSF→IFN regulatory factor 4 (IRF4)→CCL17 pathway, first identified in monocytes/macrophages, for arthritic pain and disease development. In this study, we further investigated the...
7.
Saleh R, Lee M, Khiew S, Louis C, Fleetwood A, Achuthan A, et al.
J Immunol
. 2018 Aug;
201(7):2042-2053.
PMID: 30120124
Pain is one of the most debilitating symptoms in many diseases for which there is inadequate management and understanding. CSF-1, also known as M-CSF, acts via its receptor (CSF-1R, c-Fms)...
8.
Hsu A, Lupancu T, Lee M, Fleetwood A, Cook A, Hamilton J, et al.
J Biol Chem
. 2018 Jun;
293(29):11415-11423.
PMID: 29871928
Interleukin 4 (IL4) is generally viewed as a Th2 cytokine capable of polarizing macrophages into an anti-inflammatory phenotype, whereas granulocyte macrophage-colony-stimulating factor (GM-CSF) is often viewed as a proinflammatory cytokine...
9.
Achuthan A, Lee M, Saleh R, Fleetwood A, Hamilton J, Cook A
Methods Mol Biol
. 2018 May;
1784:215-223.
PMID: 29761402
Animal models of arthritis enable us to investigate the pathogenesis of the disease and also to evaluate new therapies. Here we describe two different acute inflammatory monoarticular arthritis models (mBSA/IL1β...
10.
Lee M, Saleh R, Achuthan A, Fleetwood A, Forster I, Hamilton J, et al.
Arthritis Res Ther
. 2018 Apr;
20(1):62.
PMID: 29622035
Background: Granulocyte macrophage-colony stimulating factor (GM-CSF) has been implicated in the pathogenesis of a number of inflammatory diseases and in osteoarthritis (OA). We identified previously a new GM-CSF→Jmjd3→interferon regulatory factor...