Andres Mendez-Lucas
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Explore the profile of Andres Mendez-Lucas including associated specialties, affiliations and a list of published articles.
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18
Citations
869
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Recent Articles
1.
Kreuzaler P, Inglese P, Ghanate A, Gjelaj E, Wu V, Panina Y, et al.
Nat Metab
. 2023 Nov;
5(11):1870-1886.
PMID: 37946084
Tumors are intrinsically heterogeneous and it is well established that this directs their evolution, hinders their classification and frustrates therapy. Consequently, spatially resolved omics-level analyses are gaining traction. Despite considerable...
2.
Pimenta-Lopes C, Sanchez-de-Diego C, Deber A, Egea-Cortes A, Valer J, Alcala A, et al.
Mol Ther
. 2023 May;
31(8):2507-2523.
PMID: 37143324
Age-related and chemotherapy-induced bone loss depends on cellular senescence and the cell secretory phenotype. However, the factors secreted in the senescent microenvironment that contribute to bone loss remain elusive. Here,...
3.
Hyrossova P, Arago M, Munoz-Pinedo C, Vinals F, Garcia-Roves P, Escolano C, et al.
Cell Death Dis
. 2022 Aug;
13(8):730.
PMID: 36002449
On glucose restriction, epithelial cells can undergo entosis, a cell-in-cell cannibalistic process, to allow considerable withstanding to this metabolic stress. Thus, we hypothesized that reduced protein glycosylation might participate in...
4.
Mendez-Lucas A, Yuneva M
Cell
. 2021 Dec;
184(26):6226-6228.
PMID: 34942098
Altered metabolism of tumors offers an opportunity to use metabolic interventions as a therapeutic strategy. Lien et al. demonstrate that understanding how specific diets with different carbohydrate and fat composition...
5.
Hyrossova P, Arago M, Moreno-Felici J, Fu X, Mendez-Lucas A, Garcia-Roves P, et al.
Cancer Metab
. 2021 Jan;
9(1):1.
PMID: 33413684
Background: Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M; PCK2) is expressed in all cancer types examined and in neuroprogenitor cells. The gene is upregulated by amino acid limitation and ER-stress in an ATF4-dependent...
6.
Mendez-Lucas A, Lin W, Driscoll P, Legrave N, Novellasdemunt L, Xie C, et al.
Nat Metab
. 2020 Jul;
2(4):335-350.
PMID: 32694609
Plasticity of cancer metabolism can be a major obstacle to efficient targeting of tumour-specific metabolic vulnerabilities. Here, we identify the compensatory mechanisms following the inhibition of major pathways of central...
7.
Sellers K, Allen T, Bousamra 2nd M, Tan J, Mendez-Lucas A, Lin W, et al.
Br J Cancer
. 2019 May;
121(1):51-64.
PMID: 31114017
Background: Previous studies suggested that the metabolism is differently reprogrammed in the major subtypes of non-small cell lung cancer (NSCLC), squamous cell carcinomas (SCC) and adenocarcinomas (AdC). However, a comprehensive...
8.
Vriens K, Christen S, Parik S, Broekaert D, Yoshinaga K, Talebi A, et al.
Nature
. 2019 Feb;
566(7744):403-406.
PMID: 30728499
Most tumours have an aberrantly activated lipid metabolism that enables them to synthesize, elongate and desaturate fatty acids to support proliferation. However, only particular subsets of cancer cells are sensitive...
9.
Mendez-Lucas A, Li X, Hu J, Che L, Song X, Jia J, et al.
Cancer Res
. 2017 Jun;
77(16):4355-4364.
PMID: 28630053
Different pyruvate kinase isoforms are expressed in a tissue-specific manner, with pyruvate kinase M2 (PKM2) suggested to be the predominant isoform in proliferating cells and cancer cells. Because of differential...
10.
Semakova J, Hyrossova P, Mendez-Lucas A, Cutz E, Bermudez J, Burgess S, et al.
J Physiol Biochem
. 2016 Oct;
73(1):89-98.
PMID: 27785616
Whole body cytosolic phosphoenolpyruvate carboxykinase knockout (PEPCK-C KO) mice die early after birth with profound hypoglycemia therefore masking the role of PEPCK-C in adult, non-gluconeogenic tissues where it is expressed....