Andreas Gewies
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Explore the profile of Andreas Gewies including associated specialties, affiliations and a list of published articles.
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25
Citations
1206
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Recent Articles
1.
Schmidt H, Raj T, ONeill T, Muschaweckh A, Giesert F, Negraschus A, et al.
Proc Natl Acad Sci U S A
. 2023 Nov;
120(48):e2309205120.
PMID: 37988467
Constitutive activation of the MALT1 paracaspase in conventional T cells of (TRAF6 Binding Mutant = TBM) mice causes fatal inflammation and autoimmunity, but the involved targets and underlying molecular mechanisms...
2.
ONeill T, Gewies A, Seeholzer T, Krappmann D
Front Immunol
. 2023 Feb;
14:1111398.
PMID: 36761777
MALT1 is a core component of the CARD11-BCL10-MALT1 (CBM) signalosome, in which it acts as a scaffold and a protease to bridge T cell receptor (TCR) ligation to immune activation....
3.
ONeill T, Krappmann D, Gewies A
Bio Protoc
. 2022 Jul;
12(10):e4423.
PMID: 35813027
Although CRISPR-Cas9 genome editing can be performed directly in single-cell mouse zygotes, the targeting efficiency for more complex modifications such as the insertion of two loxP sites, multiple mutations in...
4.
Hong L, Li N, Gasque V, Mehta S, Ye L, Wu Y, et al.
JCI Insight
. 2022 Feb;
7(4).
PMID: 35108221
The molecular mechanisms that drive the acquisition of distinct neural crest cell (NCC) fates is still poorly understood. Here, we identified Prdm6 as an epigenetic modifier that temporally and spatially...
5.
ONeill T, Seeholzer T, Gewies A, Gehring T, Giesert F, Hamp I, et al.
Sci Immunol
. 2021 Nov;
6(65):eabh2095.
PMID: 34767456
Balanced control of T cell signaling is critical for adaptive immunity and protection from autoimmunity. By combining genetically engineered mouse models, biochemical analyses and pharmacological interventions, we describe an unexpected...
6.
Gewies A, Grass C, Krappmann D
Methods Mol Biol
. 2021 Jul;
2366:125-143.
PMID: 34236636
Jurkat T cells have been of central importance for the discovery of signalling mediators driving NF-κB activation in response to T cell antigen receptor (TCR)/CD28 co-stimulation. The critical function of...
7.
Li Z, He P, Luo G, Shi X, Yuan G, Zhang B, et al.
Front Pharmacol
. 2020 Oct;
11:570939.
PMID: 33071784
Background: The anticancer potential of pharmacologic ascorbic acid (AA) has been detected in a number of cancer cells. However, study suggested a strongly reduced cytotoxic activity of AA. It was...
8.
Kutukculer N, Seeholzer T, ONeill T, Grass C, Aykut A, Karaca N, et al.
J Allergy Clin Immunol
. 2020 Aug;
147(2):775-778.e8.
PMID: 32858082
No abstract available.
9.
Rosenbaum M, Gewies A, Pechloff K, Heuser C, Engleitner T, Gehring T, et al.
Nat Commun
. 2019 May;
10(1):2352.
PMID: 31138793
Regulatory T cells (Tregs) have crucial functions in the inhibition of immune responses. Their development and suppressive functions are controlled by the T cell receptor (TCR), but the TCR signaling...
10.
Kong B, Bruns P, Behler N, Chang L, Schlitter A, Cao J, et al.
Gut
. 2016 Sep;
67(1):146-156.
PMID: 27646934
Objective: The initial steps of pancreatic regeneration versus carcinogenesis are insufficiently understood. Although a combination of oncogenic Kras and inflammation has been shown to induce malignancy, molecular networks of early...