Thomas J ONeill
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Explore the profile of Thomas J ONeill including associated specialties, affiliations and a list of published articles.
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22
Citations
213
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Recent Articles
1.
Rosenlehner T, Pennavaria S, Akcabozan B, Jahani S, ONeill T, Krappmann D, et al.
Sci Signal
. 2024 Oct;
17(859):eadi8753.
PMID: 39436996
Ribosomal biosynthesis in nucleoli is an energy-demanding process driven by all RNA polymerases and hundreds of auxiliary proteins. We investigated how this process is regulated in activated T lymphocytes by...
2.
Moud B, Ober F, ONeill T, Krappmann D
Front Immunol
. 2024 Jun;
15:1412347.
PMID: 38863711
CARD-BCL10-MALT1 (CBM) signalosomes connect distal signaling of innate and adaptive immune receptors to proximal signaling pathways and immune activation. Four CARD scaffold proteins (CARD9, 10, 11, 14) can form seeds...
3.
Schmidt H, Raj T, ONeill T, Muschaweckh A, Giesert F, Negraschus A, et al.
Proc Natl Acad Sci U S A
. 2023 Nov;
120(48):e2309205120.
PMID: 37988467
Constitutive activation of the MALT1 paracaspase in conventional T cells of (TRAF6 Binding Mutant = TBM) mice causes fatal inflammation and autoimmunity, but the involved targets and underlying molecular mechanisms...
4.
ONeill T, Tofaute M, Krappmann D
Cancer Treat Rev
. 2023 May;
117:102568.
PMID: 37126937
The paracaspase MALT1 has emerged as a key regulator of immune signaling, which also promotes tumor development by both cancer cell-intrinsic and -extrinsic mechanisms. As an integral subunit of the...
5.
ONeill T, Gewies A, Seeholzer T, Krappmann D
Front Immunol
. 2023 Feb;
14:1111398.
PMID: 36761777
MALT1 is a core component of the CARD11-BCL10-MALT1 (CBM) signalosome, in which it acts as a scaffold and a protease to bridge T cell receptor (TCR) ligation to immune activation....
6.
ONeill T, Krappmann D, Gewies A
Bio Protoc
. 2022 Jul;
12(10):e4423.
PMID: 35813027
Although CRISPR-Cas9 genome editing can be performed directly in single-cell mouse zygotes, the targeting efficiency for more complex modifications such as the insertion of two loxP sites, multiple mutations in...
7.
ONeill T, Seeholzer T, Gewies A, Gehring T, Giesert F, Hamp I, et al.
Sci Immunol
. 2021 Nov;
6(65):eabh2095.
PMID: 34767456
Balanced control of T cell signaling is critical for adaptive immunity and protection from autoimmunity. By combining genetically engineered mouse models, biochemical analyses and pharmacological interventions, we describe an unexpected...
8.
Hamp I, ONeill T, Plettenburg O, Krappmann D
Expert Opin Ther Pat
. 2021 Jul;
31(12):1079-1096.
PMID: 34214002
Introduction: MALT1 is the only human paracaspase, a protease with unique cleavage activity and substrate specificity. As a key regulator of immune responses, MALT1 has attracted attention as an immune...
9.
ONeill T, Xi Y, Stehel E, Browning T, Ng Y, Baker C, et al.
Radiol Artif Intell
. 2021 May;
3(2):e200024.
PMID: 33937858
Purpose: To determine how to optimize the delivery of machine learning techniques in a clinical setting to detect intracranial hemorrhage (ICH) on non-contrast-enhanced CT images to radiologists to improve workflow....
10.
Kutukculer N, Seeholzer T, ONeill T, Grass C, Aykut A, Karaca N, et al.
J Allergy Clin Immunol
. 2020 Aug;
147(2):775-778.e8.
PMID: 32858082
No abstract available.