Andreas Ettinger
Overview
Explore the profile of Andreas Ettinger including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
616
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Recent Articles
1.
Hains A, Chetal K, Nakatani T, Marques J, Ettinger A, Junior C, et al.
Genome Biol
. 2024 Dec;
25(1):319.
PMID: 39707510
Background: The fatal diffuse midline gliomas (DMG) are characterized by an undruggable H3K27M mutation in H3.1 or H3.3. K27M impairs normal development by stalling differentiation. The identification of targetable pathways...
2.
Arner A, Ettinger A, Blaser B, Schmid B, Jeremias I, Rostam N, et al.
PLoS One
. 2024 Aug;
19(8):e0309415.
PMID: 39213296
Acute lymphoblastic leukemia (ALL) is the most common type of malignancy in children. ALL prognosis after initial diagnosis is generally good; however, patients suffering from relapse have a poor outcome....
3.
Determinants of minor satellite RNA function in chromosome segregation in mouse embryonic stem cells
Chen Y, Jones A, Crawford A, Sattler M, Ettinger A, Torres-Padilla M
J Cell Biol
. 2024 Apr;
223(7).
PMID: 38625077
The centromere is a fundamental higher-order structure in chromosomes ensuring their faithful segregation upon cell division. Centromeric transcripts have been described in several species and suggested to participate in centromere...
4.
Lalonde M, Ummethum H, Trauner M, Ettinger A, Hamperl S
Methods Cell Biol
. 2024 Feb;
182:199-219.
PMID: 38359977
Transcription-replication conflicts (TRCs) represent a potent endogenous source of replication stress. Besides the spatial and temporal coordination of replication and transcription programs, cells employ many additional mechanisms to resolve TRCs...
5.
Nakatani T, Schauer T, Altamirano-Pacheco L, Klein K, Ettinger A, Pal M, et al.
Nature
. 2023 Dec;
625(7994):401-409.
PMID: 38123678
DNA replication enables genetic inheritance across the kingdoms of life. Replication occurs with a defined temporal order known as the replication timing (RT) programme, leading to organization of the genome...
6.
Guthmann M, Qian C, Gialdini I, Nakatani T, Ettinger A, Schauer T, et al.
Genes Dev
. 2023 Apr;
37(7-8):336-350.
PMID: 37072228
The majority of our genome is composed of repeated DNA sequences that assemble into heterochromatin, a highly compacted structure that constrains their mutational potential. How heterochromatin forms during development and...
7.
Nakatani T, Lin J, Ji F, Ettinger A, Pontabry J, Tokoro M, et al.
Nat Genet
. 2022 Mar;
54(3):318-327.
PMID: 35256805
Totipotency emerges in early embryogenesis, but its molecular underpinnings remain poorly characterized. In the present study, we employed DNA fiber analysis to investigate how pluripotent stem cells are reprogrammed into...
8.
Buschle A, Mrozek-Gorska P, Cernilogar F, Ettinger A, Pich D, Krebs S, et al.
Nucleic Acids Res
. 2021 Mar;
49(6):3217-3241.
PMID: 33675667
Epstein-Barr virus (EBV), a herpes virus also termed HHV 4 and the first identified human tumor virus, establishes a stable, long-term latent infection in human B cells, its preferred host....
9.
Fischbeck A, Ruehland S, Ettinger A, Paetzold K, Masouris I, Noessner E, et al.
Front Oncol
. 2020 Dec;
10:589434.
PMID: 33364193
Adoptive T cell therapy (ACT) is highly effective in the treatment of hematologic malignancies, but shows limited success in solid tumors. Inactivation of T cells in the tumor milieu is...
10.
Huang Y, Chanou A, Kranz G, Pan M, Kohlbauer V, Ettinger A, et al.
J Biol Chem
. 2019 Jan;
294(9):3051-3064.
PMID: 30598504
Regulated intramembrane proteolysis (RIP) is a key mechanism for activating transmembrane proteins such as epithelial cell adhesion molecule (EpCAM) for cellular signaling and degradation. EpCAM is highly expressed in carcinomas...