Jeffrey van Haren
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Explore the profile of Jeffrey van Haren including associated specialties, affiliations and a list of published articles.
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23
Citations
499
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Recent Articles
1.
Wolf van der Meer J, Larue A, van der Knaap J, Chalkley G, Sijm A, Beikmohammadi L, et al.
Genes Dev
. 2025 Feb;
39(5-6):401-422.
PMID: 39919828
Pathogenic variants in the ubiquitin-specific protease 7 () gene cause a neurodevelopmental disorder called Hao-Fountain syndrome. However, it remains unclear which of USP7's pleiotropic functions are relevant for neurodevelopment. Here,...
2.
Dema A, Charafeddine R, van Haren J, Rahgozar S, Viola G, Jacobs K, et al.
Curr Biol
. 2024 Dec;
34(24):5822-5832.e5.
PMID: 39626666
Doublecortin (DCX) is a microtubule (MT)-associated protein in immature neurons. DCX is essential for early brain development, and DCX mutations account for nearly a quarter of all cases of lissencephaly-spectrum...
3.
van Zwam M, Dhar A, Bosman W, van Straaten W, Weijers S, Seta E, et al.
PLoS Biol
. 2024 Mar;
22(3):e3002551.
PMID: 38466773
Mammals have 6 highly conserved actin isoforms with nonredundant biological functions. The molecular basis of isoform specificity, however, remains elusive due to a lack of tools. Here, we describe the...
4.
Dema A, Charafeddine R, van Haren J, Rahgozar S, Viola G, Jacobs K, et al.
bioRxiv
. 2024 Mar;
PMID: 38464100
Doublecortin (DCX) is a microtubule-associated protein critical for brain development. Although most highly expressed in the developing central nervous system, the molecular function of DCX in neuron morphogenesis remains unknown...
5.
Dema A, Charafeddine R, Rahgozar S, van Haren J, Wittmann T
Elife
. 2023 Jan;
12.
PMID: 36715499
A challenge in analyzing dynamic intracellular cell biological processes is the dearth of methodologies that are sufficiently fast and specific to perturb intracellular protein activities. We previously developed a light-sensitive...
6.
Dema A, Rahgozar S, Siquier L, van Haren J, Wittmann T
Methods Mol Biol
. 2022 Apr;
2430:467-481.
PMID: 35476350
Micropatterning of extracellular matrix proteins enables defining cell position and shape in experiments investigating intracellular dynamics and organization. While such standardization is advantageous in automated and quantitative analysis of many...
7.
Stormo A, Shavarebi F, Fitzgibbon M, Earley E, Ahrendt H, Lum L, et al.
J Cell Biol
. 2022 Mar;
221(4).
PMID: 35266954
Missense mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson's disease (PD); however, pathways regulating LRRK2 subcellular localization, function, and turnover are not fully...
8.
Dema A, van Haren J, Wittmann T
Curr Biol
. 2022 Jan;
32(5):1197-1205.e4.
PMID: 35090591
Chromosome segregation is accomplished by the mitotic spindle, a bipolar micromachine built primarily from microtubules. Different microtubule populations contribute to spindle function: kinetochore microtubules attach and transmit forces to chromosomes,...
9.
Sanchez-Huertas C, Bonhomme M, Falco A, Fagotto-Kaufmann C, van Haren J, Jeanneteau F, et al.
J Cell Biol
. 2020 Jun;
219(9).
PMID: 32497170
Microtubule (MT) plus-end tracking proteins (+TIPs) are central players in the coordination between the MT and actin cytoskeletons in growth cones (GCs) during axon guidance. The +TIP Navigator-1 (NAV1) is...
10.
Wittmann T, Dema A, van Haren J
Curr Opin Cell Biol
. 2020 May;
66:1-10.
PMID: 32371345
Cell biology is moving from observing molecules to controlling them in real time, a critical step towards a mechanistic understanding of how cells work. Initially developed from light-gated ion channels...