Andrea Olland
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Explore the profile of Andrea Olland including associated specialties, affiliations and a list of published articles.
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20
Citations
386
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Recent Articles
1.
Cole A, Kultgen S, Mani N, Fan K, Ardzinski A, Stever K, et al.
J Med Chem
. 2024 Sep;
67(18):16773-16795.
PMID: 39231272
Inhibition of Hepatitis B Virus (HBV) replication by small molecules that modulate capsid assembly and the encapsidation of pgRNA and viral polymerase by HBV core protein is a clinically validated...
2.
Cole A, Kultgen S, Mani N, Ardzinski A, Fan K, Thi E, et al.
RSC Med Chem
. 2022 Apr;
13(3):343-349.
PMID: 35434625
Disruption of the HBV viral life cycle with small molecules that prevent the encapsidation of pregenomic RNA and viral polymerase through binding to HBV core protein is a clinically validated...
3.
The eptinezumab:CGRP complex structure - the role of conformational changes in binding stabilization
David L, Scalley-Kim M, Olland A, White A, Misura K
Bioengineered
. 2021 Dec;
12(2):11076-11086.
PMID: 34895054
To further elucidate the mechanism of action and binding properties of eptinezumab to calcitonin gene-related peptide (CGRP), X-ray crystallography, computational alanine scanning, and molecular dynamics were used. X-ray diffraction data...
4.
Suriben R, Chen M, Higbee J, Oeffinger J, Ventura R, Li B, et al.
Nat Med
. 2020 Jul;
26(8):1264-1270.
PMID: 32661391
Cancer cachexia is a highly prevalent condition associated with poor quality of life and reduced survival. Tumor-induced perturbations in the endocrine, immune and nervous systems drive anorexia and catabolic changes...
5.
Mullarky E, Xu J, Robin A, Huggins D, Jennings A, Noguchi N, et al.
Bioorg Med Chem Lett
. 2019 Jul;
29(17):2503-2510.
PMID: 31327531
Cancer cells reprogram their metabolism to support growth and to mitigate cellular stressors. The serine synthesis pathway has been identified as a metabolic pathway frequently altered in cancers and there...
6.
Liu S, Misquitta Y, Olland A, Johnson M, Kelleher K, Kriz R, et al.
J Biol Chem
. 2013 Jun;
288(31):22758-67.
PMID: 23792959
Phosphorylation of inhibitor of nuclear transcription factor κB (IκB) by IκB kinase (IKK) triggers the degradation of IκB and migration of cytoplasmic κB to the nucleus where it promotes the...
7.
Kovalenko O, Olland A, Piche-Nicholas N, Godbole A, King D, Svenson K, et al.
J Biol Chem
. 2013 May;
288(24):17408-19.
PMID: 23632026
The immunoglobulin new antigen receptors (IgNARs) are a class of Ig-like molecules of the shark immune system that exist as heavy chain-only homodimers and bind antigens by their single domain...
8.
Zapf C, Bloom J, Li Z, Dushin R, Nittoli T, Otteng M, et al.
Bioorg Med Chem Lett
. 2011 Jul;
21(15):4602-7.
PMID: 21715165
An extension of our previously reported series of macrocyclic ortho-aminobenzamide Hsp90 inhibitors is reported. Addition of a second methyl group to the tether provided analogs that show increased potency in...
9.
Malamas M, Robichaud A, Erdei J, Quagliato D, Solvibile W, Zhou P, et al.
Bioorg Med Chem Lett
. 2010 Oct;
20(22):6597-605.
PMID: 20880704
The identification of small molecule aminohydantoins as potent and selective human β-secretase inhibitors is reported. These analogs exhibit good brain permeability (40-70%), low nanomolar potency for BACE1, and demonstrate >100-fold...
10.
Malamas M, Barnes K, Hui Y, Johnson M, Lovering F, Condon J, et al.
Bioorg Med Chem Lett
. 2010 Mar;
20(7):2068-73.
PMID: 20223661
The proteolytic enzyme beta-secretase (BACE1) plays a central role in the synthesis of the pathogenic beta-amyloid in Alzheimer's disease. Recently, we reported small molecule acylguanidines as potent BACE1 inhibitors. However,...