Anand V Sastry
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Explore the profile of Anand V Sastry including associated specialties, affiliations and a list of published articles.
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35
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735
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Recent Articles
1.
Sastry A, Yuan Y, Poudel S, Rychel K, Yoo R, Lamoureux C, et al.
PLoS Comput Biol
. 2024 Oct;
20(10):e1012546.
PMID: 39441835
Public gene expression databases are a rapidly expanding resource of organism responses to diverse perturbations, presenting both an opportunity and a challenge for bioinformatics workflows to extract actionable knowledge of...
2.
Yuan Y, Al Bulushi T, Sastry A, Sancar C, Szubin R, Golden S, et al.
Proc Natl Acad Sci U S A
. 2024 Sep;
121(38):e2410492121.
PMID: 39269777
is an important cyanobacterium that serves as a versatile and robust model for studying circadian biology and photosynthetic metabolism. Its transcriptional regulatory network (TRN) is of fundamental interest, as it...
3.
Patel A, McGrosso D, Hefner Y, Campeau A, Sastry A, Maurya S, et al.
Nat Commun
. 2024 Jun;
15(1):5234.
PMID: 38898010
It has proved challenging to quantitatively relate the proteome to the transcriptome on a per-gene basis. Recent advances in data analytics have enabled a biologically meaningful modularization of the bacterial...
4.
Menon N, Poudel S, Sastry A, Rychel K, Szubin R, Dillon N, et al.
mSystems
. 2024 Jan;
9(2):e0060623.
PMID: 38189271
causes severe infections in humans, resists multiple antibiotics, and survives in stressful environmental conditions due to modulations of its complex transcriptional regulatory network (TRN). Unfortunately, our global understanding of the...
5.
Lamoureux C, Decker K, Sastry A, Rychel K, Gao Y, McConn J, et al.
Nucleic Acids Res
. 2023 Sep;
51(19):10176-10193.
PMID: 37713610
Transcriptomic data is accumulating rapidly; thus, scalable methods for extracting knowledge from this data are critical. Here, we assembled a top-down expression and regulation knowledge base for Escherichia coli. The...
6.
Rychel K, Tan J, Patel A, Lamoureux C, Hefner Y, Szubin R, et al.
Cell Rep
. 2023 Sep;
42(9):113105.
PMID: 37713311
Relationships between the genome, transcriptome, and metabolome underlie all evolved phenotypes. However, it has proved difficult to elucidate these relationships because of the high number of variables measured. A recently...
7.
Bajpe H, Rychel K, Lamoureux C, Sastry A, Palsson B
mSystems
. 2023 Aug;
8(5):e0043723.
PMID: 37638727
pv. DC3000 is a model plant pathogen that infects tomatoes and . The current understanding of global transcriptional regulation in the pathogen is limited. Here, we applied iModulon analysis to...
8.
Hirose Y, Poudel S, Sastry A, Rychel K, Lamoureux C, Szubin R, et al.
mSystems
. 2023 Jun;
8(3):e0024723.
PMID: 37278526
can cause a wide variety of acute infections throughout the body of its human host. An underlying transcriptional regulatory network (TRN) is responsible for altering the physiological state of the...
9.
Patel A, McGrosso D, Hefner Y, Campeau A, Sastry A, Maurya S, et al.
bioRxiv
. 2023 Mar;
PMID: 36865326
It has proved challenging to quantitatively relate the proteome to the transcriptome on a per-gene basis. Recent advances in data analytics have enabled a biologically meaningful modularization of the bacterial...
10.
Yuan Y, Seif Y, Rychel K, Yoo R, Chauhan S, Poudel S, et al.
mSystems
. 2022 Nov;
7(6):e0046722.
PMID: 36317888
Establishing transcriptional regulatory networks (TRNs) in bacteria has been limited to well-characterized model strains. Using machine learning methods, we established the transcriptional regulatory networks of six Salmonella enterica serovar Typhimurium...