Amr M Ghaleb
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Explore the profile of Amr M Ghaleb including associated specialties, affiliations and a list of published articles.
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35
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1716
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Recent Articles
1.
Agbo K, Huang J, Ghaleb A, Williams J, Shroyer K, Bialkowska A, et al.
J Cancer Metastasis Treat
. 2020 Jun;
5.
PMID: 32566755
Aim: Colorectal cancer (CRC) is the third leading cancer-related cause of death due to its propensity to metastasize. Epithelial-mesenchymal transition (EMT) is a multistep process important for invasion and metastasis...
2.
Fujikawa J, Takeuchi Y, Kanazawa S, Nomir A, Kito A, Elkhashab E, et al.
Cell Tissue Res
. 2017 Sep;
370(3):441-449.
PMID: 28856432
Kruppel-like factor 4 (KLF4) is a zinc finger transcription factor that plays crucial roles during the development and maintenance of multiple organs. We and others have previously shown that KLF4...
3.
Ghaleb A, Yang V
Gene
. 2017 Feb;
611:27-37.
PMID: 28237823
Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor that regulates diverse cellular processes such as cell growth, proliferation, and differentiation. Since its discovery in 1996, KLF4...
4.
Bialkowska A, Ghaleb A, Nandan M, Yang V
J Vis Exp
. 2016 Aug;
(113).
PMID: 27501188
Understanding the role of factors that regulate intestinal epithelial homeostasis and response to injury and regeneration is important. The current literature describes several different methodological approaches to obtain images of...
5.
Kuruvilla J, Kim C, Ghaleb A, Bialkowska A, Kuo C, Yang V
Stem Cell Reports
. 2016 May;
6(6):815-824.
PMID: 27237377
In response to ionizing radiation-induced injury, the normally quiescent intestinal stem cells marked by BMI1 participate in the regenerative response. Previously, we established a protective role for Krüppel-like factor 4...
6.
Snider A, Bialkowska A, Ghaleb A, Yang V, Obeid L, Hannun Y
Methods Mol Biol
. 2016 May;
1438:245-54.
PMID: 27150094
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), significantly increases the risk for development of colorectal cancer. Specifically, dysplasia and cancer associated with IBD (colitis-associated cancer...
7.
KLF4 Suppresses Tumor Formation in Genetic and Pharmacological Mouse Models of Colonic Tumorigenesis
Ghaleb A, Elkarim E, Bialkowska A, Yang V
Mol Cancer Res
. 2016 Feb;
14(4):385-96.
PMID: 26839262
Unlabelled: The zinc finger transcription factor Krüppel-like factor 4 (KLF4) is frequently downregulated in colorectal cancer. Previous studies showed that KLF4 is a tumor suppressor in the intestinal tract and...
8.
Kuruvilla J, Ghaleb A, Bialkowska A, Nandan M, Yang V
Stem Cell Transl Investig
. 2015 Jun;
2(2).
PMID: 26097895
The intestinal epithelium is a tissue that undergoes continuous self-renewal initiated at the bottom of the crypts, which harbor the intestinal stem cell (ISC) pool. The ISC pool is sub-divided...
9.
Ghaleb A, Bialkowska A, Snider A, Gnatenko D, Hannun Y, Yang V, et al.
PLoS One
. 2015 Jun;
10(6):e0129314.
PMID: 26047140
IQ motif-containing GTPase-activating protein 2 (IQGAP2) is a multidomain scaffolding protein that plays a role in cytoskeleton regulation by juxtaposing Rho GTPase and Ca2+/calmodulin signals. While IQGAP2 suppresses tumorigenesis in...
10.
Mallipattu S, Horne S, DAgati V, Narla G, Liu R, Frohman M, et al.
J Clin Invest
. 2015 Feb;
125(3):1347-61.
PMID: 25689250
Maintenance of mitochondrial structure and function is critical for preventing podocyte apoptosis and eventual glomerulosclerosis in the kidney; however, the transcription factors that regulate mitochondrial function in podocyte injury remain...